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MetabolomicsMechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomes and gut microbiome

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

2023-07-24 | MTBLS7808 | MetaboLights
ProteomicsIdentification of TRADD phosphorylation sites
We re-introduced Flag-mTRADD into Tradd-/- MEFs, and identified the phosphorylation sites of TRADD which were induced by TNF and inhibited by TAK1 inhibitor 5Z7 using mass spectrometry. We found that TAK1 could mediate the phosphorylation of multiple sites in TRADD upon TNF stimulation. We next perf...
ORGANISM(S): Homo Sapiens 
2024-10-05 | PXD056588 |
ProteomicsR406 binding site on TAK1 identified by MS
We identified of R406 and its pro-drug R788 for the treatment of cancer by inducing necroptosis.
ORGANISM(S): Homo Sapiens 
2023-08-28 | PXD044897 |
MetabolomicsIntegrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis.

This analysis established comprehensive metabolomic profiles of adenomyosis patients and revealed widespread alterations in the metabolome within normal and fibrotic myometrium. Integrated analysis shown significant associations between metabolomic data and fibrosis . This study is the first to d...

2025-05-12 | MTBLS11965 | MetaboLights
ProteomicsQuantitative proteomics of Chromochloris zofingiensis reveals key protein involved in cell growth and bioactive compound biosynthesis
Glucose metabolism regulates cell growth and affects astaxanthin accumulation in green algae Chromochloris zofingiensis. Hub genes function in this bioactive compound biosynthesis has been illustrated in genome, transcriptome and metabolome level, but rather limited from proteome aspects. Microalgal...
ORGANISM(S): Chromochloris Zofingiensis 
2022-06-13 | PXD034488 |
ProteomicsThe effects of exercises on proteomic characteristics of subcutaneous adipose tissue of growing high-fat diet–fed rats
To study the changes in the proteomics profile of of subcutaneous adipose tissue of growing high-fat diet–fed rats, TMT was used as the labeling strategy for comparative quantitative proteomic analysis.
ORGANISM(S): Rattus Rattus 
2023-04-14 | PXD041539 |
ProteomicsPrelamin A interacts with RIPK1 in ZMPSTE24-deficient cells
To understand the gain-of-toxicity of unprocessed prelamin A, we sought to identify the specific binding proteins of prelamin A that do not interact with mature lamin A. Because prelamin A is specifically localized to the nuclear envelope, we used ascorbate peroxidase 2 (APEX2)-based proximity label...
ORGANISM(S): Homo Sapiens 
2024-01-31 | PXD049033 |
Proteomicspp6 is recruited in TNFalpha induced complex I
We identify pp6 is recruited in complex I induced by TNFalpha.
ORGANISM(S): Mus Musculus 
2021-12-14 | PXD030377 |
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