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MetabolomicsGlutamate-mediated metabolic rewiring boosts CpxA/R-OmpF porin and proton motive force to resensitize antibiotic-resistant Escherichia coli to ceftazidime

Ceftazidime (CAZ) is a critically important broad-spectrum antibiotic widely used in clinical practice. However, the rapid emergence of bacterial resistance to CAZ poses a significant challenge in treating infections caused by multidrug-resistant pathogens. In this study, we employed a metabolism...

2026-01-20 | MTBLS13732 | MetaboLights
UnknownInteraction of infectious spleen and kidney necrosis virus ORF119L with PINCH leads to dominant-negative inhibition of integrin-linked kinase and cardiovascular defects in zebrafish.
Not available
S-EPMC4301147 | biostudies-literature
TranscriptomicsExpression data from Th2 cell of ECM1 KO mice vs WT mice
CD4+ helper T cells are critical for immunological response. Th2 cells, a subset of CD4+ helper T cells, are responsible for asthma and other immune diseases. We found a Th2 secreted protein, ExtraCellular Matrix protein 1 (ECM1), which is highly induced by classic IL-4 signaling pathway during help...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-19707 | biostudies-arrayexpress
UnknownStructural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant.
Not available
S-EPMC10688377 | biostudies-literature
UnknownSuppressive stroma-immune prognostic signature impedes immunotherapy in ovarian cancer and can be reversed by PDGFRB inhibitors.
Not available
S-EPMC10472577 | biostudies-literature
UnknownAXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation.
Not available
S-EPMC11464762 | biostudies-literature
UnknownEphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer.
Not available
S-EPMC5247645 | biostudies-literature
UnknownCetuximab plus FOLFOXIRI versus cetuximab plus FOLFOX as conversion regimen in RAS/BRAF wild-type patients with initially unresectable colorectal liver metastases (TRICE trial): A randomized controlled trial.
Not available
S-EPMC11086847 | biostudies-literature
UnknownEarly argatroban and antiplatelet combination therapy in acute non-lacunar single subcortical infarct associated with mild intracranial atherosclerosis.
Not available
S-EPMC8579679 | biostudies-literature
UnknownProbiotics synergized with conventional regimen in managing Parkinson's disease.
Not available
S-EPMC9130297 | biostudies-literature
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