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ProteomicsAsymmetrically glycosylated IgG1 antibodies are universal and drive human disease
IgG antibodies have a conserved N-linked glycan on residue Asn297 of the homodimeric Fc region that modulates antibody-mediated effector functions. These effects on the immune response are reflected in correlations between IgG glycans and numerous infectious and autoimmune diseases. However, current...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-11-18 | PXD070591 | Pride
Antibody glycosylation  intact lc/ms 
MetabolomicsCroquemort elicits activation of the immune deficiency pathway in ticks
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain e...
2023-04-27 | MTBLS686 | MetaboLights
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