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TranscriptomicsExpression profiling of lung T cell subsets from wild-type and Serpinb1a-/- mice
The aim of this study was to identify differential gene expression in lung T cell subsets upon germline Serpinb1a ablation. CD8-CD19- lymphocytes enriched by negative selection from digested lungs of naïve, 9-12 week old wild-type 129S6 mice or Serpinb1a homozygous null mice were FACS sorted into C...
ORGANISM(S): Mus musculus 
2014-04-22 | E-GEOD-46297 | biostudies-arrayexpress
TranscriptomicsExpression profiling of MDR1+ and MDR1- human memory T cells from the blood and clinically-inflamed gut tissue
The aim of this study was to characterize the transcriptional signature of MDR1+ human memory T cells isolated from clinically inflamed gut tissue, and compare it to local MDR1- memory T cells Human mononuclear cells were isolated from the peripheral blood of a healthy adult donor (Ficol density cen...
ORGANISM(S): Homo sapiens 
2013-12-17 | E-GEOD-49702 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of wild-type and Gcn2-/- Th17 cells to halofuginone and rapamycin
This study was designed to evaluate similarities and differences between transcriptional responses of developing Th17 cells to the prolyl-tRNA synthetase inhibitor, halofuginone, and the mTOR inhibitor, rapamycin. Further comparisons between wild-type and Gcn2-/- Th17 cells allow for investigation i...
ORGANISM(S): Mus musculus 
2014-05-29 | E-GEOD-47478 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiles of CCR7lo effector memory human T cell subsets
The aim of this study was to identify differentially-expressed genes in CCR4hi/CXCR3- and CCR4lo CXCR3+ CCR6+ human Th17 cell subsets Human CD45RO+ memory T cells isolated from the peripheral blood of healthy adult donors were sorted into 4 predominant CCR7lo CD25- effector memory subsets: (1) Th1 -...
ORGANISM(S): Homo sapiens 
2013-12-17 | E-GEOD-49703 | biostudies-arrayexpress
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