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GenomicsSequencing Apoptotic DNA Breakpoints
DNA fragmentation is a well-recognized hallmark of apoptosis. However, the precise DNA sequences cleaved during apoptosis triggered by distinct mechanisms remain unclear. We used next-generation sequencing of DNA fragments generated in Actinomycin D-treated human HL-60 leukemic cells to generate a h...
ORGANISM(S): Homo sapiens 
2011-10-15 | E-GEOD-32997 | biostudies-arrayexpress
UnknownPhospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection.
Not available
S-EPMC6176631 | biostudies-literature
UnknownSpoken Expressive Vocabulary in 2-Year-Old Children with Hearing Loss: A Community Study.
Not available
S-EPMC10377817 | biostudies-literature
GenomicsPregnancy-associated alterations in DNA methylation patterns of mammary epithelial stem cells [mRRBS]
Mammary gland development and luminal differentiation occur largely postnatally during puberty and pregnancy. We found that pregnancy had the most significant effects on stem cells, inducing a distinct epigenetic state that remained stable through life. Mammary glands were collected from mice at non...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-54149 | biostudies-arrayexpress
TranscriptomicsPregnancy-associated alterations in DNA methylation patterns of mammary epithelial stem cells [reproductive stages]
Mammary gland development and luminal differentiation occur largely postnatally during puberty and pregnancy. We found that pregnancy had the most significant effects on stem cells, inducing a distinct epigenetic state that remained stable through life. Mammary glands were collected from different r...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-54147 | biostudies-arrayexpress
TranscriptomicsPregnancy-associated alterations in DNA methylation patterns of mammary epithelial stem cells [inhibitor study]
Mammary gland development and luminal differentiation occur largely postnatally during puberty and pregnancy. To explore the role of DNA methylation in luminal cell differentiation and pregnancy-induced changes, we determined the genome-wide DNA methylation and gene expression profiles of mammary ep...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-54148 | biostudies-arrayexpress
GenomicsPregnancy-associated alterations in DNA methylation patterns of mammary epithelial stem cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-54150 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling in mouse plasma cell tumor precursor and bystander cells revels potential intervention targets for plasma-cell neoplasia
We extracted nascent plasma cell tumor (PCT) cells from within inflammatory granulomas (OG) isolated from intraperitoneal pristane-injected BALB/c.iMyc Eμ mice at five different time points during tumor progression. We used laser capture micro-dissection to collect incipient PCT cells and analyzed ...
ORGANISM(S): Mus musculus 
2011-12-02 | E-GEOD-34078 | biostudies-arrayexpress
UnknownA randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to central retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 5.
Not available
S-EPMC2872173 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
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