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GenomicsThe characteristics of genome-wide DNA methylation in naM-CM-/ve CD4+ T cells of patients with psoriasis and atopic dermatitis
Psoriasis and atopic dermatitis (AD) are characterized by polarized CD4+ T cell responses. During the polarization of naM-CM-/ve CD4+ T cells, DNA methylation plays an important role in the regulation of gene transcription. In this study, we profiled the genome-wide DNA methylation status of naM-CM-...
ORGANISM(S): Homo sapiens 
2012-03-17 | E-GEOD-35582 | biostudies-arrayexpress
ModelsShin2019- Regulation of nuclear factor of activated T-cells (NFAT)
A properly functioning immune system is vital for an organism's wellbeing. Immune tolerance is a critical feature of the immune system that allows immune cells to mount effective responses against exogenous pathogens such as viruses and bacteria, while preventing attack to self-tissues. Activation-i...
2020-03-20 | MODEL2003200002 | BioModels
TranscriptomicsGene expression profiles of T cell fraction enriched for donor antigen-reactive T cells in skin allografted recipient mice (II)
Measurement of specific gene expression in clinical samples is a promising approach for monitoring the recipient immune status to the graft in organ transplantation. Identification of biomarker genes closely associated with tolerance or rejection is critical for this monitoring protocol. Unlike prev...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-32953 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of T cell fraction enriched for donor antigen-reactive T cells in skin allografted recipient mice (I)
Measurement of specific gene expression in clinical samples is a promising approach for monitoring the recipient immune status to the graft in organ transplantation. Identification of biomarker genes closely associated with tolerance or rejection is critical for this monitoring protocol. Unlike prev...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-32952 | biostudies-arrayexpress
UnknownEnhanced Neonatal Brain Responses To Sung Streams Predict Vocabulary Outcomes By Age 18 Months.
Not available
S-EPMC5622081 | biostudies-literature
GenomicsGenome-wide analysis of histone modifications in latently HIV-1 infected T cells
The epigenetic mechanisms established by histone modifications may affect the transcriptional silencing of HIV-1 and viral latency. A systematic epigenome profiling could be applicable to develop new epigenetic diagnostic markers for detecting HIV-1 latency. In this study, histone modification prof...
ORGANISM(S): Homo sapiens 
2014-06-06 | E-GEOD-58247 | biostudies-arrayexpress
MetabolomicsDeciphering metabolomic alterations in seminal plasma of crossbred (Bos taurus X Bos indicus) bulls through comparative deep metabolomic analysis
The incidence of sub-fertility is higher in crossbred bulls compared to zebu bulls. In the present study, we analysed the metabolomic profile of seminal plasma from crossbred and zebu bulls and uncovered differentially expressed metabolites between these two breeds. Using a high-throughput LC-MS/MS-...
2021-12-22 | MTBLS1642 | MetaboLights
TranscriptomicsAnalysis of Mouse Dendritic and Antigen presenting cell and Mouse autoimmune and Inflammatory Response
Antigen presenting cells (APC) express receptors recognizing microbes and regulating immune responses by binding to corresponding ligands on immune cells. Having discovered a novel inhibitory pathway triggered by ligation of DC-HIL on APC to a heparin/heparan sulfate-like saccharide of syndecan-4 o...
ORGANISM(S): Mus musculus 
2010-05-06 | E-GEOD-17699 | biostudies-arrayexpress
UnknownTRAIL-Mediated Suppression of T Cell Receptor Signaling Inhibits T Cell Activation and Inflammation in Experimental Autoimmune Encephalomyelitis.
Not available
S-EPMC5786528 | biostudies-literature
UnknownLiver-resident CD103+ dendritic cells prime antiviral CD8+ T cells in situ.
Not available
S-EPMC4369411 | biostudies-literature
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