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OtherNext generation sequencing reveals no change in mtDNA deletions upon the loss of mitochondrial fusion in mouse hearts
Aim: To determine whether mtDNA deletions arise upon the loss of mitochondria fusion in heart tissue Method: DNA was isolated heart mitochondria from control and heart-specific double mitofusin1-2 (dMfn) KO animals and used to generate libraries for sequencing to detect mtDNA deletions. Total genomi...
ORGANISM(S): Mus musculus 
2018-12-28 | GSE124420 | GEO
ProteomicsOveractive mitochondrial DNA replication disrupts perinatal cardiac maturation
Proteomic analysis of the neonatal hearts of mice carrying an exonuclease-deficient DNA polymerase gamma and overexpressing Twinkle helicase. For further methodological details please refer to the associated original publication.
ORGANISM(S): Mus musculus (Mouse) 
2024-07-14 | PXD047603 | Pride
Mouse heart mitochondria mutator mtdna 
MetabolomicsGNPS - Ancestral allele of DNA polymerase gamma modifies antiviral tolerance
Mitochondria are arising as critical modulators of antiviral tolerance by releasing mtDNA/mtRNA fragments to cytoplasm upon infection, activating virus sensors and type-I interferon response. The relevance of these mechanisms for mitochondrial diseases remains understudied. Here, we investigated mit...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-11 | MSV000093634 | GNPS
ProteomicsAncestral allele of DNA polymerase gamma modifies antiviral tolerance
Mitochondria are arising as critical modulators of antiviral tolerance by releasing mtDNA/mtRNA fragments to cytoplasm upon infection, activating virus sensors and type-I interferon response. The relevance of these mechanisms for mitochondrial diseases remains understudied. Here, we investigated mit...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-11 | MSV000093634 | MassIVE
TranscriptomicsTranscription profiling of fat biopsies from monozygotic twins discordant for body mass index to elucidate the effects of acquired obesity
Elucidating the effects of acquired obesity by comparison of fat biopsies from monozygotic twins discordant for BMI.
ORGANISM(S): Homo sapiens 
2008-02-15 | E-MEXP-1425 | biostudies-arrayexpress
GenomicsNext generation sequencing reveals no change in mtDNA deletions upon the loss of mitochondrial fusion in mouse hearts
Next generation sequencing reveals no change in mtDNA deletions upon the loss of mitochondrial fusion in mouse hearts
PRJNA511990 | ENA
UnknownVegan diet in young children remodels metabolism and challenges the statuses of essential nutrients
Not available
S-SCDT-EMM-2020-13492P | biostudies-other
UnknownLoss of mitochondrial DNA helicase in retinal macroglia drives neovascular retinopathy
Not available
S-SCDT-10_1038-S44321-026-00438-0 | biostudies-other
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