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TranscriptomicsTranscription factor cooperativity in early adipogenic hotspots and super-enhancers
Here we have used a combination of advanced proteomics and genomics approaches to investigate the extent and mechanisms of transcription factor cross-talk at genomic hotspots. We identify ~12,000 transcription factor hotspots in the early phase of adipogenesis, and we find evidence of both simultane...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-56872 | biostudies-arrayexpress
GenomicsStriatal genes regulated by super-enhancers and displaying low paused RNAPII are preferentially down-regulated in Huntington’s disease [ChIP-seq]
Huntington neurodegenerative disease (HD) is associated with extensive down-regulation of neuronal genes. We show preferential down-regulation of super-enhancer-regulated neuronal function genes in the striatum of HD mice. Striatal super-enhancers display extensive H3K27 acetylation within gene bodi...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-59570 | biostudies-arrayexpress
TranscriptomicsStriatal genes regulated by super-enhancers and displaying low paused RNAPII are preferentially down-regulated in Huntington’s disease [RNA-seq]
Huntington neurodegenerative disease (HD) is associated with extensive down-regulation of neuronal genes. We show preferential down-regulation of super-enhancer-regulated neuronal function genes in the striatum of HD mice. Striatal super-enhancers display extensive H3K27 acetylation within gene bodi...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-59571 | biostudies-arrayexpress
GenomicsChIP-seq for the identification of enhancer and super enhancers in Acute Myeloid Leukemia cells with a 3q-aberration
To infer enhancers and super enhancers in Acute Myeloid Leukemia (AML) Cell lines with a 3q-aberration we determined regions enriched for H3K27AC, H3K4ME3, H3K4ME1, P300, and BRD4 in MOLM1. Additionally we determined regions enriched for P300 and BRD4 in the cell line Mutz3 which also harbors a 3q-a...
ORGANISM(S): Homo sapiens 
2014-04-03 | E-MTAB-2224 | biostudies-arrayexpress
TranscriptomicsConvergent Sense/Antisense Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability
Activation-induced cytidine deaminase (AID) initiates both somatic hypermutation (SHM) for antibody affinity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-dependent cytidine deamination of single stranded DNA targets. While largely specific for immunglob...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-62296 | biostudies-arrayexpress
GenomicsSuper-enhancers require enhancers and facilitators to fully activate gene expression [ATAC-seq]
Super-enhancers require enhancers and facilitators to fully activate gene expression [ATAC-seq]
PRJNA906957 | ENA
GenomicsSuper-enhancers require enhancers and facilitators to fully activate gene expression [RNA-seq]
Super-enhancers require enhancers and facilitators to fully activate gene expression [RNA-seq]
PRJNA906969 | ENA
GenomicsSuper-enhancers require enhancers and facilitators to fully activate gene expression [ChIP-seq]
Super-enhancers require enhancers and facilitators to fully activate gene expression [ChIP-seq]
PRJNA909806 | ENA
GenomicsSuper-enhancers require enhancers and facilitators to fully activate gene expression [Tiled-C]
Super-enhancers require enhancers and facilitators to fully activate gene expression [Tiled-C]
PRJNA906995 | ENA
GenomicsTranscriptional super-enhancers connected to cell identity and disease
Transcriptional super-enhancers connected to cell identity and disease
PRJNA223352 | ENA
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