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ProteomicsEfficient Suppression of Premature Termination Codons by Engineered Chimeric Pyrrolysine tRNAs
Mutations that introduce premature termination codons (PTCs) within protein-coding genes are associated with incurable and severe genetic diseases. Many PTC-associated disorders are life-threatening and have no approved medical treatment options. Suppressor transfer RNAs (sup-tRNAs) with the capacit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044548 | Pride
Suppressor transfer rnas (sup-trnas) Premature termination codons (ptcs) Pyrrolysine trna scaffold suppressor-trnas (pass-trnas) 
ProteomicsSwapped genetic code block viral infections and gene transfer
Removing cellular transfer RNAs (tRNAs), making their cognate codons unreadable, creates a genetic firewall that prevents viral replication and horizontal gene transfer. However, numerous viruses and mobile genetic elements encode parts of the translational apparatus, including tRNAs, potentially re...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2022-07-08 | MSV000089854 | MassIVE
ProteomicsEfficient Suppression of Premature Termination Codons by Engineered Pyrrolysine tRNAs
Mutations that introduce premature termination codons (PTCs) within protein-coding genes are associated with incurable and severe genetic diseases. Many PTC-associated disorders are life-threatening and have no approved medical treatment options. Suppressor transfer RNAs (sup-tRNAs) with the capacit...
ORGANISM(S): Escherichia coli 
2025-02-20 | PXD044322 | Pride
Proteomics Mutations Premature termination codons Trna Bacteria Gfp 
OtherNonviral delivery of chemically modified tRNA rescues nonsense mutations [Ribo-Seq]
Suppressor transfer RNAs (sup-tRNAs) can rescue disease-causing nonsense mutations by promoting readthrough of premature termination codons (PTCs). Their clinical translation is limited by suboptimal activity and inefficient in vivo delivery. In this work, we combined site-specific chemical modifica...
ORGANISM(S): Homo sapiens 
2026-08-27 | GSE326898 | GEO
OtherNonviral delivery of chemically modified tRNA rescues nonsense mutations
Suppressor transfer RNAs (sup-tRNAs) can rescue disease-causing nonsense mutations by promoting readthrough of premature termination codons (PTCs). Their clinical translation is limited by suboptimal activity and inefficient in vivo delivery. In this work, we combined site-specific chemical modifica...
ORGANISM(S): Homo sapiens 
2026-08-27 | GSE326462 | GEO
TranscriptomicsTherapeutic efficacy of sup-tRNA in CFTR-mutated human bronchial epithelial (HBE) cells
Suppressor transfer RNAs (sup-tRNAs) can rescue disease-causing nonsense mutations by promoting readthrough of premature termination codons (PTCs). Their clinical translation is limited by suboptimal activity and inefficient in vivo delivery. In this work, we combined site-specific chemical modifica...
ORGANISM(S): Homo sapiens 
2026-08-27 | GSE303837 | GEO
OtherEfficient suppression of premature termination codons with alanine by engineered chimeric pyrrolysine tRNAs [Ribo-Seq]
Mutations that introduce premature termination codons (PTCs) within protein-coding genes are associated with incurable and severe genetic diseases. Many PTC-associated disorders are life-threatening and have no approved medical treatment options. Suppressor transfer RNAs (sup-tRNAs) with the capacit...
ORGANISM(S): Homo sapiens 
2024-12-27 | GSE277130 | GEO
TranscriptomicsEfficient suppression of premature termination codons with alanine by engineered chimeric pyrrolysine tRNAs
Mutations that introduce premature termination codons (PTCs) within protein-coding genes are associated with incurable and severe genetic diseases. Many PTC-associated disorders are life-threatening and have no approved medical treatment options. Suppressor transfer RNAs (sup-tRNAs) with the capacit...
ORGANISM(S): Homo sapiens 
2024-12-27 | GSE277128 | GEO
ProteomicstRNA-m1A Methylation Regulates the Infection of Magnaporthe oryzae by Supporting Ergosterol Biosynthesis
Ergosterols are essential components of fungal plasma membranes. Inhibitors targeting ergosterol biosynthesis (ERG) genes are critical for controlling fungal pathogens, including Magnaporthe oryzae, the fungus that causes rice blast. In this study we show that the Trm6/Trm61 complex catalyzes dynami...
ORGANISM(S): Pyricularia Oryzae 70-15 
2024-06-07 | PXD051352 |
UnknownEfficient suppression of premature termination codons with alanine by engineered chimeric pyrrolysine tRNAs.
Not available
S-EPMC11662663 | biostudies-literature
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