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TranscriptomicsTranscription profiling of mouse at ages P4 and P60 in sciatic nerve of wild type and with peripheral neuropathies to study disease mechanisms in peripheral neuropathies due to altered Pmp22 gene dosage or a Pmp22 point mutation
We compared gene expression at ages P4 and P60 in sciatic nerve of wild type mice and mice with peripheral neuropathies caused by altered Pmp22 gene dosage (homozygous knockout or transgene) or a point mutation (Trembler).
ORGANISM(S): Mus musculus 
2007-11-03 | E-GEOD-1947 | biostudies-arrayexpress
TranscriptomicsFunctions of HDAC1 and HDAC2 in Schwann cells during postnatal
The aim of our study is to determine the functions of histone deacetylases (HDACs) 1 and 2 in Schwann cells during postnatal development of the peripheral nervous system (PNS). Schwann cells are the myelinating glial cells of the PNS. At birth, mouse sciatic nerves mature in 2 subsequent phases: 1/ ...
ORGANISM(S): Mus musculus 
2011-02-25 | E-GEOD-27451 | biostudies-arrayexpress
TranscriptomicsMetabolic control of adult neural stem cell activity by FASN-­dependent lipogenesis
Mechanisms controlling the proliferative activity of neural stem/progenitor cells (NSPCs) play a pivotal role to ensure life-long neurogenesis in the mammalian brain. How metabolic programs are coupled with NSPC activity remains unknown. Here we show that fatty acid synthase (FASN), the key enzyme o...
ORGANISM(S): Mus musculus 
2012-11-02 | E-GEOD-27391 | biostudies-arrayexpress
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