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TranscriptomicsMax as a biological blockade that restricts meiotic process in ESCs
We explored Max ablation-mediated up-regulation of germ-related genes, especially meiosis-related genes in mouse embryonic stem cells which were cultured either under conventional mouse ES medium or 2i condition using inhibitors against MEK and GSK3b. Effect of culture conditions (conventional mouse...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-65700 | biostudies-arrayexpress
TranscriptomicsIdentification of Ccr4-Not complex as a regulator of transition from partial to genuine iPS cells
Partial induced pluripotent cells (iPSCs) are cell lines strayed from normal route from somatic cells to iPSCs and are immortalized. Mouse partial iPSCs are able to convert to real iPSCs by the exposure to 2i condition using MAPK and GSK3? inhibitors. However, the molecular mechanisms of this conver...
ORGANISM(S): Mus musculus 
2014-01-07 | E-GEOD-44339 | biostudies-arrayexpress
TranscriptomicsThe forced expression of Nanog or Esrrb allows preserve ESC status in the absence of nucleostemin expression
Nucleostemin (NS) gene is known to be expressed in stem cells in general including embryonic stem cells (ESCs). Previous knockdown and knockout studies have demonstrated that NS is important for the preservation of their self-renewality and high levels of pluripotent marker gene expression in mouse ...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-56797 | biostudies-arrayexpress
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