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TranscriptomicsP15 Rat Sciatic Nerve ChIP-Chip with NuRD complex components
The NuRD complex is required for efficient and timely myelination in the peripheral nervous system. ChIP-chip assays were performed on rat sciatic nerve at P15, a peak timepoint of myelination, for binding of Chd4 to genes involved in regulating myelin formation. This experiment includes two custom...
ORGANISM(S): Rattus norvegicus 
2011-07-25 | E-GEOD-30890 | biostudies-arrayexpress
TranscriptomicsH4IIE liver cell line ChIP-Chip with Egr1
Egr1 regulates genes involved in cholesterol biosynthesis in liver. ChIP-chip assays were performed on H4IIE liver cells that were either treated or untreated with insulin for one hour. This experiment includes a custom ChIP-chip design incorporating many genes that are dynamically regulated by ins...
ORGANISM(S): Rattus norvegicus 
2011-07-22 | E-GEOD-30823 | biostudies-arrayexpress
GenomicsSox10 Binding Analysis in the Central and Peripheral Nervous System
ChIP-seq of Sox10 in spinal cord and sciatic nerve 2 independent Sox10 ChIP samples each for spinal cord (CNS) and sciatic nerve (PNS), with respective inputs
ORGANISM(S): Rattus norvegicus 
2015-04-01 | E-GEOD-64703 | biostudies-arrayexpress
TranscriptomicsSciatic nerve FAIRE-chip and ChIP-Chip with Egr2/Krox20 and Sox10
Egr2/Krox20 and Sox10 regulate genes involved in formation of myelination in the peripheral nervous system. ChIP-chip assays were performed on rat sciatic nerve at P15, a peak timepoint of myelination. In addition, Faire was used to identify areas of open chromatin. This experiment includes a custom...
ORGANISM(S): Rattus norvegicus 
2010-10-14 | E-GEOD-23648 | biostudies-arrayexpress
GenomicsGenome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve
We provide ChIP-Seq analysis of Egr2 and Sox10 transcription factor binding in Schwann cells of rat peripheral nerve ChIP-Seq analysis of Egr2 and Sox10 binding in P15 rat sciatic nerve. Wiggle files of negative log of posterior probability determined by Mosaics.
ORGANISM(S): Rattus norvegicus 
2012-04-01 | E-GEOD-35132 | biostudies-arrayexpress
UnknownHaplotype-specific modulation of a SOX10/CREB response element at the Charcot-Marie-Tooth disease type 4C locus SH3TC2.
Not available
S-EPMC4168306 | biostudies-literature
UnknownFailures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Not available
S-EPMC7819709 | biostudies-literature
TranscriptomicsFailures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from slow axon growth. This impairs axonal regeneration and ca...
ORGANISM(S): Mus musculus 
2020-10-14 | E-MTAB-9640 | biostudies-arrayexpress
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