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TranscriptomicsAging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene (DNA Methylation)
Aging is a progressive process that results in the accumulation of intra- and extracellular alterations that in turn contribute to a reduction in health. Age-related changes in DNA methylation have been reported before and may be responsible for aging-induced changes in gene expression, although a c...
ORGANISM(S): Homo sapiens 
2014-05-09 | E-GEOD-49064 | biostudies-arrayexpress
TranscriptomicsEffects of PGRMC1 phosphorylation on genome integrity and epigenetics
Progesterone receptor membrane component 1 (PGRMC1) is a protein that has been implicated in cancer biology and poor patient outcomes, which can be over-expressed in cancers, and exist in alternative states of phosphorylation.Here, we show that manipulation of PGRMC1 phosphorylation by mutagenesis r...
ORGANISM(S): Homo sapiens 
2019-12-01 | E-MTAB-8218 | biostudies-arrayexpress
TranscriptomicsApplication of a low cost array-based technique - TAB-Array - for quantifying and mapping both 5mC and 5hmC at single base resolution.
5-hydroxymethylcytosine (5hmC), an oxidized derivative of 5-methylcytosine (5mC), has been implicated as an important epigenetic regulator of mammalian development. Current procedures use cost-prohibitive DNA sequencing methods to discriminate 5hmC from 5mC, limiting their accessibility to the scie...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-60225 | biostudies-arrayexpress
TranscriptomicsDNA methylation of matched primary-metastases medulloblastomas
DNA methylation was generated from 11 pairs of matched primary-metastases medulloblastoma samples using the Illumina Infinium HumanMethylation450 BeadChip array Total DNA was extracted from primary and metastases medulloblastoma samples, bisulfite converted and hybridized to Illumina Infinium HumanM...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-63669 | biostudies-arrayexpress
TranscriptomicsDNA methylation differences between human regulatory T cells and conventional T cells
Regulatory T cells (Treg) prevent the emergence of autoimmune disease. Prototypic natural Treg (nTreg) are programmed by Forkhead-box P3 (FOXP3) and can be reliably identified by demethylation at the FOXP3 locus. To explore the nTreg methylation landscape we performed genome-wide methylation studies...
ORGANISM(S): Homo sapiens 
2013-09-09 | E-GEOD-49667 | biostudies-arrayexpress
TranscriptomicsAn Epigenetic Signature in Peripheral Blood Associated with Neurodegenerative Tauopathy and the Risk-Associated Haplotype on 17q21.31
Progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) are two neurodegenerative diseases linked, at the pathologic and genetic level, to the macrutubule associated protein tau. We identified and replicated a dose-dependent effect of the risk-associated H1 haplotype on methylation le...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-53740 | biostudies-arrayexpress
TranscriptomicsAdditional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array
Background: Measurement of genome-wide DNA methylation (DNAm) has become an important avenue for investigating potentially functional changes in various pathological conditions. Illumina Infinium is a relatively inexpensive and user-friendly DNAm microarray platform used by many researchers to measu...
ORGANISM(S): Homo sapiens 
2013-03-04 | E-GEOD-42409 | biostudies-arrayexpress
UnknownUsing global team science to identify genetic parkinson's disease worldwide.
Not available
S-EPMC7410260 | biostudies-literature
UnknownLanguage impairment is associated with faster progression in progressive supranuclear palsy-Richardson syndrome.
Not available
S-EPMC12276069 | biostudies-literature
UnknownA multimodality test to guide the management of patients with a pancreatic cyst.
Not available
S-EPMC7859881 | biostudies-literature
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