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The goal is the characterization of the off-target activity of BKM120 observed in A2058 human melanoma cell line at IC90 concentration (3.606 µM) but not at lower concentrations. Controls are BEZ235, GDC0941, showing no off-target activity. A secondary objective is the characterizations of drug eff...
ORGANISM(S): Homo sapiens 
The absence of a Ca(2+) signal during mouse egg activation can affect parthenogenetic preimplantation development, gene expression patterns, and blastocyst quality. Gene expression pattern of parthenogenetic mouse embryos by cycloheximide or Sr2+. Keywords: development or differentiation design Gene...
ORGANISM(S): Mus musculus 
gene expression pattern of parthenogenetic mouse embryos by cycloheximide or Sr2+.
ORGANISM(S): Mus musculus 

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
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