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GenomicsGenome-wide profile of the SWI/SNF chromatin remodeling complex
A systems understanding of nuclear organization and events is critical for determining how cells divide, differentiate and respond to stimuli and for identifying the causes of diseases. Chromatin remodeling complexes such as SWI/SNF have been implicated in a wide variety of cellular processes includ...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24397 | biostudies-arrayexpress
TranscriptomicsA SWI/SNF nucleosome remodeling complex acts in non-coding RNA-mediated transcriptional silencing
RNA-mediated transcriptional silencing prevents deleterious effects of transposon activity and controls the expression of protein-coding genes. It involves long non-coding RNAs (lncRNAs)1, which in Arabidopsis thaliana are produced by a specialized RNA Polymerase V (Pol V)2. lncRNAs guide Argonaute-...
ORGANISM(S): Arabidopsis thaliana 
2012-12-01 | E-GEOD-38400 | biostudies-arrayexpress
GenomicsThe Swi/Snf tumor suppressor complex establishes nucleosome occupancy at target promoters [ChIP-seq]
Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these patterns are established and dynamically maintained and subsequently contribute to transcriptional control are poorly understood. The Swi/Snf...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-46587 | biostudies-arrayexpress
TranscriptomicsThe Swi/Snf tumor suppressor complex establishes nucleosome occupancy at target promoters [expression]
Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these patterns are established and dynamically maintained and subsequently contribute to transcriptional control are poorly understood. The Swi/Snf...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-46645 | biostudies-arrayexpress
GenomicsThe Swi/Snf tumor suppressor complex establishes nucleosome occupancy at target promoters [Mnase-Seq II]
Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these patterns are established and dynamically maintained and subsequently contribute to transcriptional control are poorly understood. The Swi/Snf...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-46586 | biostudies-arrayexpress
TranscriptomicsANGUSTIFOLIA 3 binds SWI/SNF chromatin remodeling complexes to regulate transcription during Arabidopsis leaf development
The transcriptional coactivator ANGUSTIFOLIA 3 (AN3) stimulates cell proliferation during Arabidopsis leaf development, but the molecular mechanism is largely unknown. We show here that inducible nuclear localization of AN3 during initial leaf growth results in differential expression of important t...
ORGANISM(S): Arabidopsis thaliana 
2014-09-09 | E-GEOD-42875 | biostudies-arrayexpress
GenomicsThe Swi/Snf tumor suppressor complex establishes nucleosome occupancy at target promoters [Mnase-Seq I]
Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these patterns are established and dynamically maintained and subsequently contribute to transcriptional control are poorly understood. The Swi/Snf...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-38670 | biostudies-arrayexpress
ProteomicsExploring the interaction between the SWI/SNF chromatin remodeling complex and the zinc finger factor CTCF
The transcription factor CCCTC-binding factor (CTCF) modulates pleiotropic functions mostly related to gene expression regulation. The role of CTCF in large scale genome organization is also well established. A unifying model to explain relationships between many CTCF-mediated activities involve dir...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022037 | Pride
Ctcf  swi/snf  brg1  mass spectrometry  protein‐protein interaction  brk  transcription factor  chromatin 
ProteomicsThe nuclear granule Paraspeckles interacts with the chromatin remodeling SWI/SNF complex to regulate alternative splicing
Protein samples were analyzed by Multidimensional Protein Identification Technology (MudPIT), as described previously. Briefly, precipitated proteins were resuspended in 30uL of 100mM Tris pH 8.5 with 8M urea to denature proteins. Cysteines were reduced and alkylated prior to digestion with recombi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-04 | MSV000089198 | MassIVE
TranscriptomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (RNA-seq)
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52623 | biostudies-arrayexpress
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