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GenomicsResistance mechanisms to SYK inhibition in AML
Resistance mechanisms to SYK inhibition in AML
PRJNA532524 | ENA
TranscriptomicsTranscription profiling and genotyping of 26 human mantle cell lymphoma samples
Among B-cell lymphomas mantle cell lymphoma (MCL) has the worst prognosis. By using a combination of genomic and expression profiling (Affymetrix GeneChip Mapping 10k Xba131 and U133 set), we analysed 26 MCL samples to identify genes relevant to MCL pathogenesis and that could represent new therapeu...
ORGANISM(S): Homo sapiens 
2007-06-24 | E-GEOD-4176 | biostudies-arrayexpress
ProteomicsA common cell state in Triple Negative Breast Cancers can be targeted through inhibition of Spleen Tyrosine Kinase (SYK)
Breast tumors are highly heterogeneous and for many molecular subtypes no targeted therapies are available. These include breast cancers that display hallmarks of epithelial to mesenchymal transition (EMT), a process related to metastasis and enriched in triple negative breast cancers (TNBCs). To de...
ORGANISM(S): Homo sapiens (Human) 
2016-06-15 | PXD001680 | Pride
Syk inhibition Phosphotyrosine proteomics Human breast cancer 
ProteomicsHSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling
Burkitt’s lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080781 | MassIVE
TranscriptomicsResistance mechanisms to SYK inhibition in AML
Targeted therapy studies with small molecules against kinases, such as spleen tyrosine kinase (SYK), are underway in patients with acute myeloid leukemia (AML) and show promising initial results. Identifying the potential mechanism of resistance and finding new drug combinations to overcome them, ho...
ORGANISM(S): Homo sapiens 
2020-01-16 | GSE129698 | GEO
TranscriptomicsGene expression profiling of two diffuse large B-cell lymphoma (DLBCL) cell lines, DHL4 and DHL6, treated with the SYK inhibitor, R406
The two DLBCL cell lines were treated with R406 to assess the signature of SYK inhibition. In previous studies, R406 decreased the proliferation and induced apoptosis of these surface Ig+ cell lines. In the previous studies, R406 inhibited the autophosphorylation of SYK 525/526 and SYK-dependent pho...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-34176 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of five diffuse large B-cell lymphoma (DLBCL) cell lines, DHL4, DHL6, LY7, HBL1 and U2932, treated with the SYK inhibitor, R406
The five DLBCL cell lines were treated with R406 to assess the signature of SYK inhibition. In previous studies, R406 decreased the proliferation and induced apoptosis of these surface Ig+ cell lines. In the previous studies, R406 inhibited the autophosphorylation of SYK 525/526 and SYK-dependent ph...
ORGANISM(S): Homo sapiens 
2013-08-31 | E-GEOD-43510 | biostudies-arrayexpress
GenomicsSYK activity modulates the EGFR-dependent transcriptome
SYK activity modulates the EGFR-dependent transcriptome
PRJNA417718 | ENA
GenomicsPTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling
PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling
PRJNA1398868 | ENA
GenomicsMacrophage Syk-PI3Kγ-HIF axis controls tumor immune suppression
Macrophage Syk-PI3Kγ-HIF axis controls tumor immune suppression
PRJNA473813 | ENA
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