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Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
MetabolomicsDelayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations in the gut microbiome, i.e., the microorganisms and their genes within the gastrointestinal tract. Maturation of the infant immune system and gut microbiota occur in parallel; ...
2024-10-24 | MTBLS7919 | MetaboLights
MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. congolense assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-10-22 | MTBLS1309 | MetaboLights
MetabolomicsCharacterizing the nasal metabolome and exposome by LC-HRMS: Opportunities and challenges

The nasal cavity represents a host-microbial interface critical to respiratory defense against viral infections, including those caused by influenza virus, respiratory syncytial virus, rhinovirus or SARS-CoV-2. Although the nasal microbiome itself has been well characterized, the nasal metabolome...

2026-10-22 | MTBLS14409 | MetaboLights
UnknownMultiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.
Not available
S-EPMC7615263 | biostudies-literature
MetabolomicsMetaboKit: a comprehensive data extraction tool for untargeted metabolomics (Mouse liver assays)

We have developed MetaboKit, a comprehensive software package for compound identification and relative quantification in mass spectrometry-based untargeted metabolomics analysis. In data dependent acquisition (DDA) analysis, MetaboKit constructs a customized spectral library with compound identit...

2021-11-02 | MTBLS1266 | MetaboLights
UnknownAnti-cholinergic drug burden in patients with dementia increases after hospital admission: a multicentre cross-sectional study.
Not available
S-EPMC9541078 | biostudies-literature
UnknownRationale and design of CHD PULSE: Congenital Heart Disease Project to Understand Lifelong Survivor Experience.
Not available
S-EPMC11806948 | biostudies-literature
UnknownGermline copy number variants and endometrial cancer risk.
Not available
S-EPMC11576655 | biostudies-literature
UnknownMapping autism risk loci using genetic linkage and chromosomal rearrangements.
Not available
S-EPMC4867008 | biostudies-literature
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