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MetabolomicsSNAP25 inhibits glioma progression by regulating synapse plasticity via GLS-mediated glutaminolysis

INTRODUCTION: Neuronal activity regulated by synaptic communication exerts an important role in tumorigenesis and progression in brain tumors. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the function ‘vesicle’ about syn...

2021-08-12 | MTBLS2806 | MetaboLights
TranscriptomicsThe 3’UTR of FMR1 mRNA is a target of miR101, miR129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse.
While FMR1 is silenced in Fragile X syndrome (FXS), its expression is elevated (2-8 fold) in premutated individuals. These people may develop the Fragile X-associated Tremor Ataxia Syndrome (FXTAS), a late onset neurodegenerative disorder characterized by ataxia and parkinsonism. In addition, people...
ORGANISM(S): Mus musculus 
2013-03-07 | E-GEOD-43670 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of mouse hippocampal neuronal cultures during development
The expression of components of the synapse proteome was examined in genome-wide transcriptome profiles of differentiating hippocampus neurons (from 0.25 to 16 days in vitro) and microelectrode arrays was used to correlate the gene expression with electrical activity.
ORGANISM(S): Mus musculus 
2007-02-26 | E-MEXP-878 | biostudies-arrayexpress
ProteomicsT-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles
The present dataset contains proteomics data from extracellular vesicles steadily released by donor matched, cultured human CD4+ and CD8+ T cells and from extracellular vesicles released within the immunological synapse.
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033917 | Pride
T-cells Immunological synapse Extracellular vesicles 
TranscriptomicsTranscription profiling of rat control subplate neurons with few synapses and cocultured subplate neurons with induced synaptogenesis
The transcriptional events accompanying synaptogenesis are largely unknown, or have been studied in systems in which synapse formation occurs gradually over time. With a system in which synaptogenesis is synchronized and controllable, molecular or biochemical techniques can be used to examine cellu...
ORGANISM(S): Rattus norvegicus 
2008-11-29 | E-GEOD-8318 | biostudies-arrayexpress
TranscriptomicsMicroarray dataset of gene transcription in mouse microglia and peripheral monocytes in contextual fear conditioning
Using Illumina MouseWG-6v2 microarrays, we investigated the gene transcription changes in microglia and peripheral monocytes after contextual fear conditioning of C57BL/6J mice. Mice were trained with or without a single minimized footshock stimulation (0-s or 2-s, 0.4 mA) and re-exposed to the trai...
ORGANISM(S): Mus musculus 
2022-10-28 | E-MTAB-12361 | biostudies-arrayexpress
ProteomicsZebrafish synaptic proteome - Evolution of complexity in the zebrafish synapse proteome
The proteome of human brain synapses is highly complex and mutated in over 130 diseases. This complexity arose from two whole genome duplications early in the vertebrate lineage. Zebrafish are used in modelling human diseases, however its synapse proteome is uncharacterised and whether the teleost-s...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Mus musculus (Mouse) 
2017-03-06 | PXD005630 | Pride
Synapse Zebrafish Evolution 
GenomicsSynapse-centered novel omics targets in Alzheimer’s disease
Synapse-centered novel omics targets in Alzheimer’s disease
PRJNA1158813 | ENA
ProteomicsSNX27 interactome during immune synapse formation
T lymphocyte recognition of antigenic peptides on the surface of antigen-presenting cells (APC) leads to immune synapse formation (IS). By analogy with the nervous synapse, this cell-cell communication model requires the formation of highly organized structures that delimit an active zone of membran...
ORGANISM(S): Homo sapiens (Human) 
2017-05-11 | PXD003628 | Pride
Snx27 Immune synapse Zo-2 T-lymphocyte Pdz 
TranscriptomicsExpression profiles of globular bushy cells (GBCs) during maturation
Calyx of Held giant presynaptic terminals in the medial nucleus of the trapezoid body of the auditory brainstem form axosomatic synapses that have advanced to one of the best-studied synaptic system of the mammalian brain. As the auditory system matures and adjusts to high fidelity synaptic transmis...
ORGANISM(S): Rattus norvegicus 
2014-06-24 | E-GEOD-49599 | biostudies-arrayexpress
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