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TranscriptomicsThe miRNA pathway controls rapid changes in activity-dependent synaptic structure at the Drosophila melanogaster neuromuscular junction (miRNA array)
It is widely accepted that long-term changes in synapse structure and function are mediated by rapid activity-dependent gene transcription and new protein synthesis. A growing amount of evidence suggests that the microRNA (miRNA) pathway plays an important role in coordinating these processes. Despi...
ORGANISM(S): Drosophila melanogaster 
2013-02-01 | E-GEOD-43943 | biostudies-arrayexpress
TranscriptomicsThe miRNA pathway controls rapid changes in activity-dependent synaptic structure at the Drosophila melanogaster neuromuscular junction (RT-PCR)
It is widely accepted that long-term changes in synapse structure and function are mediated by rapid activity-dependent gene transcription and new protein synthesis. A growing amount of evidence suggests that the microRNA (miRNA) pathway plays an important role in coordinating these processes. Despi...
ORGANISM(S): Drosophila melanogaster 
2013-02-01 | E-GEOD-43944 | biostudies-arrayexpress
ProteomicsGonatopoulos-Pournatzis _eIF4Gmicroexon_P105_Lumos
A This dataset consists of 24 raw MS files, acquired on Orbitrap Fusion Lumos Tribrid mass spectrometer operated in Data Dependent Acquisition mode. B Mouse samples were generated by Thomas Gonatopoulos-Pournatzis. Proteomics sample preparation and mass spectrometric acquisition was performed by Sh...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-12-04 | MSV000084658 | MassIVE
TranscriptomicsTranscription profiling of human Alzheimers disease patients to identify genes regulating synaptic function and neuroplasticity in incipient AD
In Alzheimer's disease (AD), early deficits in learning and memory are a consequence of synaptic modification which are likely induced by toxic beta-amyloid oligomers (dAbeta). To identify molecular targets downstream of dAbeta binding we prepared synaptoneurosomes from frontal cortex of control a...
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-12685 | biostudies-arrayexpress
GenomicsAutism-misregulated eIF4G microexons control synaptic translation and higher-order cognitive functions [Ribo-Seq]
Autism-misregulated eIF4G microexons control synaptic translation and higher-order cognitive functions [Ribo-Seq]
PRJNA594022 | ENA
GenomicsAutism-misregulated eIF4G microexons control synaptic translation and higher-order cognitive functions [iCLIP-seq]
Autism-misregulated eIF4G microexons control synaptic translation and higher-order cognitive functions [iCLIP-seq]
PRJNA594023 | ENA
GenomicsLocal translation is engaged to sustain synaptic function in impaired Wallerian degeneration
Local translation is engaged to sustain synaptic function in impaired Wallerian degeneration
PRJNA1124852 | ENA
TranscriptomicsMETTL3 promotes translation in human cancer cells
we find METTL3 associates with polyribosomes and promotes translation. METTL3 depletion inhibits translation, and both wild-type and catalytically inactive METTL3 promote translation when tethered to the 3' untranslated region (UTR) of a reporter mRNA. Mechanistically, METTL3 enhances mRNA translati...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-76367 | biostudies-arrayexpress
GenomicsDevelopment of nanoRibo-seq enables study of regulated translation by cortical neuron subtypes, showing uORF translation in synaptic-axonal genes
Development of nanoRibo-seq enables study of regulated translation by cortical neuron subtypes, showing uORF translation in synaptic-axonal genes
PRJNA808741 | ENA
TranscriptomicsFunctionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience
The subcellular localization and translation of messenger RNA (mRNA) supports functional differentiation between cellular compartments. In neuronal dendrites, local translation of mRNA provides a rapid and specific mechanism for synaptic plasticity and memory formation, and might be involved in the ...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-58343 | biostudies-arrayexpress
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