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ProteomicsA Novel Human Cellular System for Studying Normal Aging and for Anti-Aging Discovery
Aging studies using animal and cellular models have uncovered key proteins and pathways central to organismal aging. However, these models differ genetically and physiologically from human aging, posing challenges in translating discoveries to human contexts. In this study, we present a human normal...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD071811 | Pride
Aging Senescence Syncytiotrophoblasts (stbs) Trophoblast stem cells (htscs) 
TranscriptomicsMatrix directs trophoblast differentiation in a bioprinted organoid model of early placental development
Trophoblast organoids can provide crucial insights into mechanisms of placentation, however their potential is limited by highly variable extracellular matrices unable to reflect in vivo tissues. Here, we present a bioprinted placental organoid model, generated using the first trimester trophoblast ...
ORGANISM(S): Homo sapiens 
2025-07-28 | GSE279994 | GEO
UnknownSingle-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy.
Not available
S-EPMC10864176 | biostudies-literature
ProteomicsMatrix directs trophoblast differentiation in a bioprinted organoid model of early placental development
Trophoblast organoids offer a unique opportunity to study mechanisms orchestrating placental growth and development during pregnancy. However, many organoid cultures rely on extracellular matrix reagents that are highly variable and unable to be tuned to reflect in vivo tissues. Here we describe the...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD056796 | Pride
Matrigel Shotgun Organoid Bioprinting Placenta 
UnknownMatrix directs trophoblast differentiation in a bioprinted organoid model of early placental development.
Not available
S-EPMC12432263 | biostudies-literature
TranscriptomicsEndogenous retrovirus MER50-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization [RNA-Seq]
Multinucleated syncytiotrophoblasts (STBs), which are in direct contact with maternal blood, constitute the maternal-fetal interface critical for nutrient allocation, hormone production and immunological modulation during pregnancy. However, the genetic and epigenetic regulatory mechanisms governing...
ORGANISM(S): Homo sapiens 
2023-02-03 | GSE209976 | GEO
GenomicsEndogenous retrovirus MER50-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization [ChIP-Seq]
Multinucleated syncytiotrophoblasts (STBs), which are in direct contact with maternal blood, constitute the maternal-fetal interface critical for nutrient allocation, hormone production and immunological modulation during pregnancy. However, the genetic and epigenetic regulatory mechanisms governing...
ORGANISM(S): Homo sapiens 
2023-02-03 | GSE209975 | GEO
TranscriptomicsTranscriptome profiling of human cytomegalovirus-infected trophoblasts
Placental infection plays a central role in the pathogenesis of congenital human cytomegalovirus (HCMV) infections and is a cause of fetal growth restriction and pregnancy loss. HCMV can replicate in some trophoblast cell types, but it remains unclear how the virus evades antiviral immunity in the p...
ORGANISM(S): Homo sapiens 
2023-12-14 | GSE248772 | GEO
UnknownA Novel Human Cellular System for Studying Normal Aging and for Anti-Aging Discovery.
Not available
S-EPMC12816977 | biostudies-literature
UnknownDysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage.
Not available
S-EPMC8080798 | biostudies-literature
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