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TranscriptomicsTranscription profiling by array of Pseudomonas aeruginosa wild-type and phhR mutants grown in a defined synthetic cystic fibrosis sputum medium with and without aromatic amino acids
Arrays comparing Pseudomonas aeruginosa growth in a defined synthetic cystic fibrosis sputum medium with and without aromatic amino acids. Additional arrays comparing wild-type Pseudomonas aeruginosa and phhR mutant P. aeruginosa in defined synthetic cystic fibrosis sputum medium.
ORGANISM(S): Pseudomonas aeruginosa 
2010-04-01 | E-MEXP-2593 | biostudies-arrayexpress
GenomicsIn vitro evolution of Pseudomonas aeruginosa AA2 biofilms in the presence of cystic fibrosis lung microbiome members
P. aeruginosa was cultured in a MultiScreen-Mesh plate, which has a filter at the bottom of the wells. The plate was immersed in either in medium alone (control) or in medium inoculated with a mixture of five bacterial strains commonly found in cystic fibrosis sputum (\"microbiome\"). The filter pre...
ORGANISM(S): Pseudomonas aeruginosa 
2019-09-13 | E-MTAB-7331 | biostudies-arrayexpress
GenomicsIdentification of adaptive mechanisms leading to reduced antibiotic susceptibility in bacterial biofilms using experimental evolution. Part 3: Pseudomonas aeruginosa floating biofilms in synthetic cystic fibrosis medium
Pseudomonas aeruginosa was repeatedly and intermittently exposed to tobramycin. Bacteria were grown in synthetic cystic fibrosis medium in wells of a 96-well microtiter plate. After 24 hours, more medium with or without tobramycin was added. After another 24 hours of incubation, a subsample of the w...
ORGANISM(S): Pseudomonas aeruginosa 
2022-08-18 | E-MTAB-11894 | biostudies-arrayexpress
GenomicsExperimental evolution of Pseudomonas aeruginosa biofilms exposed to furanone C-30 with and without tobramycin
The aim of this study is to evaluate the evolutionary robustness of the quorum sensing inhibitor (QSI) furanone C-30 for the treatment of P. aeruginosa biofilm infections. We repeatedly exposed P. aeruginosa biofilms to furanone C-30 (with or without tobramycin) in the synthetic cystic fibrosis sput...
ORGANISM(S): Pseudomonas aeruginosa 
2021-03-05 | E-MTAB-10124 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics reveals species-specific metabolite production and shared nutrient consumption by Pseudomonas aeruginosa and Staphylococcus aureus

While bacterial metabolism is known to impact antibiotic efficacy and virulence, the metabolic capacities of individual microbes in cystic fibrosis lung infections are difficult to disentangle from sputum samples. Here, we show that untargeted metabolomic profiling of supernatants of multiple str...

2021-05-26 | MTBLS2105 | MetaboLights
TranscriptomicsTranscriptional profiling of P. aeruginosa isolated from 3 individuals with cystic fibrosis over time
Pseudomonas aeruginosa chronically colonizes the lungs of individuals with CF, where it reaches high cell densities and produces a battery of virulence factors. Upon infection, a single strain of P. aeruginosa can colonize an individual’s lungs throughout his or her lifetime. To understand the evo...
ORGANISM(S): Pseudomonas aeruginosa 
2010-06-08 | E-GEOD-21966 | biostudies-arrayexpress
UnknownUnique Features of Mycobacterium abscessus Biofilms Formed in Synthetic Cystic Fibrosis Medium.
Not available
S-EPMC8586431 | biostudies-literature
ProteomicsUnraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of Pseudomonas aeruginosa in an organotypic 3-D lung epithelial cell model
Pseudomonas aeruginosa chronically infects the lungs of people with cystic fibrosis (pwCF), where it produces a broad range of proteases that impact host immunity and inflammation. While some studies suggest these enzymes induce inflammation and may contribute to the excessive inflammatory response ...
ORGANISM(S): Homo sapiens (Human) Pseudomonas aeruginosa PAO1 
2025-10-23 | PXD065321 | Pride
Cystic fibrosis Proteomics Inflammation Elastase b Pseudomonas aeruginosa Bacterial proteases Virulence factors 
ProteomicsR_OM_Metapyo_32_CF_patients_C18_pos
we analyzed the metabolome content by untargeted HPLC/HRMS (see supplementary information). Isolates were first grown in synthetic CF medium 2 (SCFM2), a culture medium designed to mimick the nutritional conditions in CF pulmonary mucus (Turner et al. 2014). Intracellular metabolic extracts of mid-l...
ORGANISM(S): Pseudomonas Aeruginosa (ncbitaxon:287) 
2020-01-10 | MSV000084790 | MassIVE
ProteomicsR_OM_Metapyo_32_CF_patients_HILIC_neg
idem R_OM_Metapyo_32_CF_patients_C18_pos we analyzed the metabolome content by untargeted HPLC/HRMS (see supplementary information). Isolates were first grown in synthetic CF medium 2 (SCFM2), a culture medium designed to mimick the nutritional conditions in CF pulmonary mucus (Turner et al. 2014). ...
ORGANISM(S): Pseudomonas Aeruginosa 
2020-01-10 | MSV000084791 | MassIVE
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