Synthetic lethal interactions

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Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences.Shenzhen 518055，China (1)

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Synthetic Lethal Interaction Between Oncogenic KRAS Dependency and Suppression of STK33 in Human Cancer Cells

Many human oncogenes are challenging therapeutic targets. An alternative to direct targeting of oncogenes is to perform â??synthetic lethalityâ?? screens for genes that are essential only in the context of specific cancer-causing mutations. We used high-throughput RNA interference (RNAi) to identify...

ORGANISM(S): Homo sapiens

2009-06-24 | E-GEOD-15151 | biostudies-arrayexpress

Probing nucleosome function: A highly versatile library of synthetic histone H3 and H4 mutants

The structural integrity of the nucleosome is central to regulation of DNA metabolism and transcription. We describe a library of 486 systematic histone H3 and H4 substitution and deletion mutants in Saccharomyces cerevisiae that probe the contribution of each residue to nucleosome function and can ...

ORGANISM(S): Saccharomyces cerevisiae

2008-09-18 | E-GEOD-10860 | biostudies-arrayexpress

Synthetic lethal screening with small molecule inhibitors provides a pathway to rational combination therapies for melanoma

Recent data demonstrate that extracellular signals are transmitted through a network of proteins rather than hierarchical signaling pathways. This network model suggests why inhibition of a single component of a canonical pathway, even when targeting a mutationally activated driver of cancer, has in...

ORGANISM(S): Homo sapiens

2012-12-06 | E-GEOD-39192 | biostudies-arrayexpress

Synthetic lethal and resistance interactions with BET bromodomain inhibitors [Barcode_seq]

PRJNA542347 | ENA

Synthetic lethal and resistance interactions with BET bromodomain inhibitors [ATAC-Seq]

PRJNA542340 | ENA

Synthetic lethal and resistance interactions with BET bromodomain inhibitors [RNA-Seq]

PRJNA542764 | ENA

Synthetic lethal and resistance interactions with BET bromodomain inhibitors [ChIP-Seq]

PRJNA542646 | ENA

Synthetic lethal and resistance interactions with BET bromodomain inhibitors [scRNA-Seq]

PRJNA542701 | ENA