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GenomicsARID1A KLF5 synthetic lethality CRISPR screen in U2OS cells
ARID1A KLF5 synthetic lethality CRISPR screen in U2OS cells
PRJEB75512 | ENA
TranscriptomicsDevelopment of gene expression signatures for knockdown of synthetic lethal gene
We performed genome-wide expression profiling analysis to define the genes underlying the synthetic-lethal relationship between CBP and p300. We extracted 1,936 genes whose expression levels changed >2-fold upon p300-knockdown (KD) in CBP-KO cells, or upon CBP-KD in p300-KO cells, but not in either ...
ORGANISM(S): Homo sapiens 
2015-12-12 | E-GEOD-73682 | biostudies-arrayexpress
GenomicsSynthetic lethality by TET-dioxygenase inhibition
Synthetic lethality by TET-dioxygenase inhibition
PRJNA682029 | ENA
TranscriptomicsSML1 synthetic lethality
Assessment of synthetic lethality between an sml1 null mutation and Yeast Deletion mutations Keywords = SML1 Keywords = yeast Keywords = deletion Keywords = synthetic lethality Keywords = tag Keywords = barcode Keywords: repeat sample
ORGANISM(S): Saccharomyces cerevisiae 
2004-11-05 | GSE1765 | GEO
TranscriptomicsSGS1 synthetic lethality
Assessment of synthetic lethality between an sgs1 null mutation and Yeast Deletion mutations Keywords = SGS1 Keywords = yeast Keywords = deletion Keywords = synthetic lethality Keywords = tag Keywords = barcode Keywords: repeat sample
ORGANISM(S): Saccharomyces cerevisiae 
2004-11-05 | GSE1757 | GEO
TranscriptomicsBIM1 synthetic lethality
Assessment of synthetic lethality between a bim1 null mutation and Yeast Deletion mutations Keywords = BIM1 Keywords = yeast Keywords = deletion Keywords = synthetic lethality Keywords = tag Keywords = barcode Keywords: repeat sample
ORGANISM(S): Saccharomyces cerevisiae 
2004-11-05 | GSE1756 | GEO
TranscriptomicsCIN8 Synthetic Lethality
Assessment of synthetic lethality between a cin8 deletion mutation and Yeast Deletion mutations. Keywords = CIN8 Keywords = yeast Keywords = deletion Keywords = synthetic lethality Keywords = tag Keywords = barcode Keywords: repeat sample
ORGANISM(S): Saccharomyces cerevisiae 
2004-11-05 | GSE1754 | GEO
ProteomicsInvestigating Synthetic Lethality and PARP Inhibitor Resistance in Pancreatic Cancer Through Enantiomer Differential Activity
The RAD51-BRCA2 interaction is central to DNA repair through homologous recombination. Emerging evidence indicates RAD51 overexpression and its correlation with chemoresistance in various cancers, suggesting RAD51-BRCA2 inhibition as a compelling avenue for intervention. We previously showed that co...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054120 | Pride
Anticancer drugs  homologous recombination  parp inhibitors  protein-protein small molecule inhibitors  parpi resistance  within-pathway synthetic lethality (wpsl) 
TranscriptomicsSynthetic Lethality (SLAM) Project Data
Synthetic lethality is a type of genetic interaction in which two non-lethal mutations acting together result in a loss of viability. Such interactions are important for the insights they may offer into how gene functions are organized into distinct cellular processes. The datasets in this Series re...
ORGANISM(S): Saccharomyces cerevisiae 
2013-02-28 | E-GEOD-14217 | biostudies-arrayexpress
GenomicsGraph transformer guided synthetic lethality prediction
Graph transformer guided synthetic lethality prediction
PRJNA1094989 | ENA
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