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MetabolomicsA synthetic community system for probing microbial interactions driven by exometabolites
Despite that most microorganisms live as part of community, we have modest knowledge about the interactions among microbial community members in nature, and the implications of those interactions for emergent community properties or ecosystem-relevant functions. To facilitate advances in understandi...
2017-10-26 | MTBLS525 | MetaboLights
MetabolomicsSilent guardians: Potentiators enhance synthetic microbiomes to combat co-contamination

Environmental co-contamination presents significant challenges. To tackle these, while microbial consortia offer advantages over single-strain approaches, such as functional redundancy and synergistic degradation, rationally designing effective synthetic microbiomes specifically for complex ...

2025-11-20 | MTBLS12809 | MetaboLights
ProteomicsEngineering consortia by polymeric microbial swarmbots
Synthetic microbial consortia represent a new frontier for synthetic biology given that they can solve more complex problems than monocultures. However, most attempts to co-cultivate these artificial communities fail because of the ‘‘winner-takes-all’’ in nutrients competition. In soil, multiple spe...
ORGANISM(S): Escherichia coli 
2022-07-04 | PXD034417 | Pride
Synthetic microbial consortia  spatial segregation  polymeric microcapsules  division of labor  communication 
ProteomicsCommunity context reshapes microbial proteomes and reduces functional overlap
Microbial coexistence in complex communities requires mechanisms that minimize competition and optimize resource use. Here, we show that bacteria modulate protein abundance in response to specific community members, reducing functional redundancy and promoting metabolic complementarity. Using synthe...
ORGANISM(S): Anaerobutyricum hallii DSM 3353 Faecalibacterium prausnitzii Roseburia intestinalis L1-82 Marvinbryantia formatexigens DSM 14469 Megasphaera elsdenii DSM 20460 Butyrivibrio fibrisolvens DSM 3071 Xylanibacter ruminicola 
2026-02-19 | PXD071838 | Pride
Microbial productivity Proteomics Gut microbiome Synthetic communities 
UnknownConstruction of synthetic microbial consortia for 2-keto-L-gulonic acid biosynthesis.
Not available
S-EPMC8671096 | biostudies-literature
TranscriptomicsTemporal RNASeq of C. difficile cultured within synthetic multispecies biofilm relative to C. difficile monoculture biofilms.
This experiment was performed largely to capture the dynamic transcriptional changes occurring in C. difficile when cultured within a 9 species synthetic gut communal consortium over a 48 h time series when cultured as a biofilm in vitro.
ORGANISM(S): Clostridioides difficile 
2026-09-23 | E-MTAB-15646 | biostudies-arrayexpress
UnknownSpatiotemporal Dynamics of Synthetic Microbial Consortia in Microfluidic Devices.
Not available
S-EPMC6754295 | biostudies-literature
ProteomicsLFQ values with shared and unique peptides - Community context reshapes microbial proteomes and reduces functional overlap
Microbial coexistence in complex communities requires mechanisms that minimize competition and optimize resource use. Here, we show that bacteria modulate protein abundance in response to specific community members, reducing functional redundancy and promoting metabolic complementarity. Using synthe...
ORGANISM(S): Anaerobutyricum hallii DSM 3353 Faecalibacterium prausnitzii Marvinbryantia formatexigens DSM 14469 Roseburia intestinalis L1-82 Butyrivibrio fibrisolvens DSM 3071 Megasphaera elsdenii DSM 20460 Xylanibacter ruminicola 
2026-02-19 | PXD073583 | Pride
ProteomicsScaffold_pairwise, single and consortia
The bacterial strains P. ruminicola ATCC 19189, M. elsdenii DSM 20460, B. fibrisolvens DSM 3071, E. hallii DSM 3353, R. intestinalis DSM 14610, M. formatexigens DSM 14469 and F. prausnitzii DSM 17677 were cultivated as single cultures, in pairwise cultures and full consortia. Bacteria were grown ana...
ORGANISM(S): Anaerobutyricum hallii DSM 3353 Faecalibacterium prausnitzii Marvinbryantia formatexigens DSM 14469 Roseburia intestinalis L1-82 Butyrivibrio fibrisolvens DSM 3071 Megasphaera elsdenii DSM 20460 Xylanibacter ruminicola 
2026-02-19 | PXD072222 | Pride
Microbial productivity Proteomics Gut microbiome Synthetic communities 
UnknownEngineering consortia by polymeric microbial swarmbots.
Not available
S-EPMC9256712 | biostudies-literature
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