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MetabolomicsSilent guardians: Potentiators enhance synthetic microbiomes to combat co-contamination

Environmental co-contamination presents significant challenges. To tackle these, while microbial consortia offer advantages over single-strain approaches, such as functional redundancy and synergistic degradation, rationally designing effective synthetic microbiomes specifically for complex ...

2025-11-20 | MTBLS12809 | MetaboLights
MetabolomicsA synthetic community system for probing microbial interactions driven by exometabolites
Despite that most microorganisms live as part of community, we have modest knowledge about the interactions among microbial community members in nature, and the implications of those interactions for emergent community properties or ecosystem-relevant functions. To facilitate advances in understandi...
2017-10-26 | MTBLS525 | MetaboLights
MetabolomicsNarrow-spectrum resource-utilizing bacteria drive the stability of synthetic communities through enhancing metabolic interactions
The importance of synthetic microbial communities in agriculture is increasingly being recognized, but methods for constructing targeted synthetic communities using existing microbial resources remain limited. In this study, six plant beneficial bacterial strains with distinct capacities for utilizi...
2025-07-11 | MTBLS12572 | MetaboLights
MetabolomicsCross-kingdom synthetic microbiota suppresses wheat Fusarium crown rot by remodeling the rhizosphere microbiome and metabolome

Wheat is a major staple crop grown across the globe. Fusarium crown rot (FCR) of wheat, caused by Fusarium pseudograminearum, is a destructive soil-borne disease that lacks effective sustainable control measures. Here, we assembled a cross-kingdom synthetic microbial community (SMC) comprising Tr...

2025-09-06 | MTBLS12946 | MetaboLights
MetabolomicsDeciphering the in vitro interaction dynamics of synthetic mucosal-associated gut bacteria community

Maintaining the integrity of the mucus layer is essential for host health. Studies have implicated that reduced or abnormal mucus production may lead to intestinal inflammation. When dietary nutrients are abundant in the gut, mucin degradation by microbes decreases. However, when nutrient availab...

2025-07-18 | MTBLS11724 | MetaboLights
MetabolomicsA synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance

The lack of new drugs that are effective against antibiotic-resistant bacteria has caused increasing concern in global public health. Based on this study, we report development of a modified antimicrobial drug through structure-based drug design (SBDD) and modular synthesis. The optimal modified ...

2024-07-03 | MTBLS10516 | MetaboLights
TranscriptomicsTemporal RNASeq of C. difficile cultured within synthetic multispecies biofilm relative to C. difficile monoculture biofilms.
This experiment was performed largely to capture the dynamic transcriptional changes occurring in C. difficile when cultured within a 9 species synthetic gut communal consortium over a 48 h time series when cultured as a biofilm in vitro.
ORGANISM(S): Clostridioides difficile 
2026-09-23 | E-MTAB-15646 | biostudies-arrayexpress
TranscriptomicsGene expression in synthetic nasal medium
Staphylococcus aureus prefers the human anterior nares as its habitat, but nothing is known about the nutritional situation in this ecological niche. Analysis of nasal secretions showed a complex mixture of nutrients at low concentration. Based on these findings a synthetic nasal medium (SNM) was co...
ORGANISM(S): Staphylococcus aureus 
2013-04-10 | E-GEOD-43712 | biostudies-arrayexpress
ProteomicsHigh-Throughput Part Characterization and Tool Development to Advance Chloroplast Synthetic Biology
Plant synthetic biology holds promise for developing climate-resilient crop varieties particularly through advancements in engineering the chloroplast genome. However, the field faces limitations due to the scarcity of genetic tools and the long generation times of photosynthetic eukaryotes. To addr...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-08-11 | PXD051642 | Pride
Chlamydomonas reinhardtii Synthetic biology 
UnknownModes of therapeutic delivery in synthetic microbiology.
Not available
S-EPMC9877134 | biostudies-literature
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