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TranscriptomicsExpression data from mouse SEOC tumors
We have developed mouse models for serous epithelial ovarian cancer (SEOC) based on conditional inactivation of p53 and Rb tumor suppression (RB-TS) in combination with or without Brca1/2 following injection of adenovirus expressing Cre recombinase into the ovarian bursa. These models develop metast...
ORGANISM(S): Mus musculus 
2013-04-19 | E-GEOD-46169 | biostudies-arrayexpress
TranscriptomicsExpression analysis of murine primary and derived orthotopic SEOC tumors
We previously generated genetically engineered mouse (GEM) models based on perturbation of Tp53, Rb with or without Brca1 or Brca2 that develop serous epithelial ovarian cancer (SEOC) closely resembling the human disease on histologic and molecular levels. We have adapted these GEM models to ortho...
ORGANISM(S): Mus musculus 
2013-10-30 | E-GEOD-51927 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression in mouse placentas with different combination of MT1-MMP and MT2-MMP alleles
MT1-MMP and MT2-MMP double deficiency in mice leads to development of a placental defect resulting in embryonic death after E10.5. The protein substrate for these two proteases in placenta is unknown, which poses an obstacle in uncovering of molecular mechanism behind the observed placental defect. ...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-18604 | biostudies-arrayexpress
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