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TranscriptomicsLicensing of PPARg-regulated gene expression by IL-4-induced alternative macrophage activation
This SuperSeries is composed of the following subset Series: GSE16385: Expression data from human macrophages GSE16386: Expression data from human alternatively activated macrophages GSE25088: PPARg and IL-4-induced gene expression data from wild-type and STAT6 knockout mouse bone marrow-derived mac...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-16387 | biostudies-arrayexpress
TranscriptomicsExpression data from human macrophages
Human CD14 positive monocytes were purified from healthy volunteers’ blood and cultured in vitro for 4, 12, 24, 72 hours. While culturing, macrophages were activated alternatively with interleukin-4 (IL-4 100 ng/ml) or classically with interferon-gamma (IFNg 100 ng/ml)+tumor necrosis factor (TNF 50 ...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-16385 | biostudies-arrayexpress
TranscriptomicsPPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived alternatively activated macrophages and immature dendritic cells (iDCs)
Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed, the other is null) and lysozyme Cre transgenic mice. PPARg and IL-4 signaling was analyzed on bone marrow-derived macrophages. Bone marrow of 4 mice per group was is...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25125 | biostudies-arrayexpress
TranscriptomicsExpression data from human alternatively activated macrophages
Human CD14 positive monocytes were purified from healthy volunteers’ blood and cultured in vitro for 6 hours. While culturing, macrophages were activated alternatively with interleukin-4 (IL-4 100 ng/ml). Simultaneously, macrophages were also treated with vehicle (DMSO:ethanol) or 1uM synthetic PPAR...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-16386 | biostudies-arrayexpress
TranscriptomicsPPARg and IL-4-induced gene expression data from wild-type and STAT6 knockout mouse bone marrow-derived macrophages
C57Bl/6 wild-type and STAT6 KO mice were used to study PPARg and IL-4 signaling. Bone marrow of 3 mice per group was isolated and differentiated to macrophages with M-CSF (20 ng/ml). 20 ng/ml IL-4 was used to induce alternative macrophage activation and 1 uM Rosiglitazone (RSG) was used to activate ...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25088 | biostudies-arrayexpress
TranscriptomicsPPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived macrophages
Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed, the other is null) and lysozyme Cre transgenic mice. PPARg and IL-4 signaling was analyzed on bone marrow-derived macrophages. Bone marrow of 3 mice per group was is...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25123 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of human dendritic cells
Human CD14 positive monocytes were purified from healthy volunteers' blood and were differentiated to immature dendritic cells in vitro by culturing for five days in the presence of interleukin-4 (IL-4 100 ng/ml) and GM-CSF (75 ng/ml). Immature dendritic cells were activated three different ways for...
ORGANISM(S): Homo sapiens 
2011-05-08 | E-GEOD-29131 | biostudies-arrayexpress
ProteomicsFunctional proteomics defines a PRC2-G9A interaction network and reveals ZNF518B as a G9A regulator
Not available
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2014-12-17 | MSV000078980 | MassIVE
TranscriptomicsCOPD-Specific Gene Expression Signatures of Alveolar Macrophages as well as Peripheral Blood Monocytes Overlap and Correlate with Lung Function
Rationale: Chronic Obstructive Pulmonary Disease (COPD) is considered a chronic inflammatory disease characterized by progressive airflow limitation and also has significant extrapulmonary (systemic) effects that lead to comorbid conditions. Very little is known about the pathomechanism of the disea...
ORGANISM(S): Homo sapiens 
2011-04-18 | E-GEOD-16972 | biostudies-arrayexpress
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