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ProteomicsGamma ray irradiation of epithelial carcinoma cells under hypoxic conditions
We demonstrate for the first time that under hypoxic conditions, A431 epithelial carcinoma cells exhibit increased viability when exposed to low-dose γ-irradiation, indicating that radiotherapy can promote tumor cell survival when oxygen supply is limited. When assessed using iTRAQ quantitative prot...
ORGANISM(S): Homo sapiens (Human) 
2017-02-27 | PXD003937 | Pride
Cancer Hypoxia Itraq Radiotherapy Calcium signaling pathway 
ProteomicsIn vivo murine brain protein synthesis uncover the molecular physiological process in brain
Identification of proteins that are synthesised de novo in response to specific microenvironmental cues is critical for understanding the molecular mechanisms, which underpin vital physiological processes and pathologies. Here, we report that a brief period of pulsed SILAM (Stable Isotope Labeling o...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-23 | PXD013502 | Pride
Pulsed silam Psivom Brain physiology Actively translating protein 
ProteomicsVascular bed systematic profiling unravels endothelial and glycocalyx dysregulations in experimental high salt hypertension
Objective: Considerable evidence links dietary salt intake with the development of hypertension, left ventricular hypertrophy, and increased risk of stroke and coronary heart disease. Despite extensive epidemiological and basic science interrogation of the relationship between high salt (HS) intake ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD031228 | Pride
Cardiovascular disease  endothelial cell dysfunction  glycocalyx  high salt diet  hypertension  mass spectrometry  proteomics   
ProteomicsSelective labeling and eradication of antibiotic tolerant bacterial populations in pathogenic biofilms
Drug resistance and tolerance eliminate the therapeutic potential of antibiotics against pathogens. Antibiotic tolerance by bacterial biofilms often leads to persistent infections, but its mechanisms are unclear. To uncover antibiotic tolerance mechanisms in biofilms, we applied stable isotope label...
ORGANISM(S): Pseudomonas aeruginosa PAO1H2O 
2016-02-16 | PXD002369 | Pride
Biofilm 
OtherExtracellular vesicles are rapidly purified from human plasma by PRotein Organic Solvent PRecipitation (PROSPR).
Data from ProteomeXchange, PXD ID: PXD002668. File: UltraCushion_R1_28.mzml. Published as part of Sci Rep. 2015 Sep 30;5:14664 . From the Abstract: {{i}} Extracellular vesicles (EVs) such as exosomes and microvesicles mediate intercellular communication and regulate a diverse range of crucial biolo...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310024861 | GPMDB
Resource Reanalysis 
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