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GenomicsGenome-wide regulatory analysis reveals T-bet controls Th17 lineage differentiation through direct suppression of IRF4
The complex relationship between Th1 and Th17 cells is incompletely understood. The transcription factor T-bet is best known as the master regulator of Th1 lineage commitment. However, attention is now focused on the repression of alternate T cell subsets mediated by T-bet, particularly the Th17 lin...
ORGANISM(S): Mus musculus 
2013-12-03 | E-GEOD-40623 | biostudies-arrayexpress
TranscriptomicsT-bet-depended but IFN-gamma-independent genes in GVHD
Given T-bet is a master regulator for Th1 differentiation that produce IFN-gamma, underlining mechanisms accounted for the distinct GVHD outcomes caused by T-bet- versus IFN-gamma-deficient donor T cells are unclear. We hypothesize that GVHD is regulated by T-bet-dependent but IFN-gamma-independe...
ORGANISM(S): Mus musculus 
2014-10-30 | E-MTAB-2198 | biostudies-arrayexpress
GenomicsEarly T-helper 1 Differentiation Is Marked by A Follicular Helper-like Transition: Differential Roles of STAT4 and T-bet
Follicular helper T (Tfh) cells comprise an important subset of helper T cells; however, their relationship with other helper lineages is incompletely understood. Herein, we show IL-12 acting via signal transducer and activator of transcription 4 (STAT4) induced both Il21 and Bcl6 genes, generating ...
ORGANISM(S): Mus musculus 
2011-12-27 | E-GEOD-33802 | biostudies-arrayexpress
TranscriptomicsTOX2 regulates human natural killer cell development by controlling T-BET expression
Thymocyte selection-associated high mobility group box protein family member 2 (TOX2) is a transcription factor belonging to the TOX family that shares a highly conserved high mobility group DNA binding domain with the other TOX members. While TOX1 has been shown to be an essential regulator of T-ce...
ORGANISM(S): Homo sapiens 
2014-12-22 | E-GEOD-58589 | biostudies-arrayexpress
TranscriptomicsT-bet regulated genes in KG1 cells
T-bet is pivotal for initiation and perpetuation of Th1 immunity. Identification of novel T-bet regulated genes is crucial for further understanding the biology of this transcription factor. By combining siRNA technology with genome-wide mRNA analysis, we sought to identify new T-bet regulated genes...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-37595 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization and transcription profiling of human and mouse T cells in differentiation
ChIP-Chip for T-bet and GATA-3 in human Th1 and Th2 cells, gene expression profiling of human Th1 and Th2 cells and of T-cells from T-bet-deficient mice,
ORGANISM(S): Homo sapiens 
2009-10-26 | E-TABM-759 | biostudies-arrayexpress
TranscriptomicsThe Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses
T-bet is a critical transcription factor for T helper 1 (Th1) cell differentiation. To study the regulation and functions of T-bet, we developed a T-bet-ZsGreen reporter mouse strain, in which GFP faithfully reflects the expression of T-bet. By using this tool, we report that signals elicited by IL...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-38808 | biostudies-arrayexpress
TranscriptomicsATAC-seq in naive B cells, CD11c+T-bet+ B cells, CD11c-T-bet- B cells from Bm12-induced lupus T-bet reporter mice
To test the chromatin accessibility of different immune cell subsets, we isolated naive B cells CD11c+T-bet+ B cells, CD11c-T-bet- B cells by flow cytometry from Bm12-induced lupus T-bet reporter mice and performed ATAC assay.
ORGANISM(S): Mus musculus 
2025-05-16 | E-MTAB-12903 | biostudies-arrayexpress
GenomicsActive STAT5 in CD8 T cells imprints a T-Bet-dependent Tc-1 program with repressed IL-6/ TGFb1 signaling leading to enhanced anti-tumor responses
CD8 T cells (TCs) expressing active STAT5 (STAT5CA) transcription factors were found to be superior to un-manipulated counterparts in their long-term persistence, capacity to infiltrate a tumor, thrive in its microenvironment and induce its regression. STAT5CA induced sustained expression of genes c...
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-41818 | biostudies-arrayexpress
TranscriptomicsT-bet and GATA-3 act in combination through distal regulatory elements across the genome
Gene expression measurements in Thp, Th1 and Th2 cells polarised from naIve CD4+ T-cells isolated from wildtype and T-bet fl/fl x Cd4-Cre BALB/c mice or from WT and Gata-3 fl/fl x Tnfrsf4-Cre C57BL/6 mice.
ORGANISM(S): Mus musculus 
2012-10-29 | E-TABM-1187 | biostudies-arrayexpress
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