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ProteomicsSystematic mutagenesis of TFIIH subunit p52/Tfb2 identifies residues required for XPB/Ssl2 subunit function and genetic interactions with TFB6
TFIIH is an evolutionarily conserved complex that plays central roles in both RNA polymerase II (pol II) transcription and DNA repair. As an integral component of the pol II Pre-Initiation Complex (PIC), TFIIH regulates pol II enzyme activity in numerous ways. The TFIIH subunit XPB/Ssl2 is an ATP-de...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD036107 | Pride
Tfiih p52/tfb2 xpb/ssl2 tfb6 
ProteomicsIdentification of CDK8 and CDK19 substrates in human cells using cortistatin A and quantitative phosphoproteomics
Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we report here the first large-scale identification of Mediator kinase substrates in human cells (HCT116). Among over 16,000 quantified sites, we identified 78 high-confidence Mediator kinase targets...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD003698 | Pride
Orbitrap velos Proteomics Mediator Quantitative Silac Orbitrap ltq Hct116 Colorectal carcinoma Cdk19 Cortistatin a Phosphoproteomics Cdk8 
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