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TranscriptomicsIdentification of genes responsive to mild hyperthermia in human cervical squamous cell carcinoma HeLa cells
Hyperthermia (HT) is widely used to treat patients with various cancers. In general, HT elicits a wide spectrum of stress responses such as induction of heat shock proteins, protein aggregation and cell death in mammalian cells. Although many biological processes are affected by HT, the overall resp...
ORGANISM(S): Homo sapiens 
2013-01-24 | E-GEOD-43701 | biostudies-arrayexpress
TranscriptomicsIdentification of genes that are regulated by TAK1 in human cutaneous T cell lymphoma HuT-102 cells
We previously reported that human T cell lymphotropic virus 1 (HTLV-1) Tax oncoprotein constitutively activates TAK1. Here, we established Tax-positive HuT-102 cells stably downregulated TAK1 expression by short-hairpin RNA (HuT-shTAK1 cells), and investigated the physiological function of TAK1. Mic...
ORGANISM(S): Homo sapiens 
2009-08-18 | E-GEOD-16219 | biostudies-arrayexpress
TranscriptomicsIdentification of genes responsive to mild hyperthermia in human oral squamous cell carcinoma HSC-3 cells
Hyperthermia (HT) is widely used to treat patients with various cancers. In general, HT elicits a wide spectrum of stress responses, such as induction of heat shock proteins, protein aggregation and cell death in mammalian cells. Although many biological processes are affected by HT, the overall res...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-GEOD-43862 | biostudies-arrayexpress
TranscriptomicsIdentification of genes involved in apoptosis induced by sodium fluoride in rat oral epithelial cells
Although an appropriate range of fluoride is thought to be safe and effective, excessive fluoride intake results in toxic effects in either hard tissues of teeth and skeleton or soft tissues of kidney, lung and brain. It is also well known that fluoride at a millimolar range elicits the complex cell...
ORGANISM(S): Rattus norvegicus 
2014-01-09 | E-GEOD-53937 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in HSF1-knockdown human oral squamous cell carcinoma HSC-3 cells
Heat shock transcription factor 1 (HSF1) is recognized as the major regulator of the heat shock transcriptional response, and also plays a central role in the cellular functions of cancer cells. Here, to identify the molecular mechanism by which HSF1 regulates the proliferation of cancer cells, comp...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-38058 | biostudies-arrayexpress
TranscriptomicsIdentification of genes responsive to mild hyperthermia in human skin normal fibroblast Hs68 cells
Hyperthermia is widely used to treat patients with various cancers. Here, the effects of heat stress at 41M-BM-0C for 30 min (mild hyperthermia) on the gene expression in Hs68 human skin normal fibroblast cells were investigated using an Affymetrix GeneChip system. The cells were treated with mild h...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-39177 | biostudies-arrayexpress
TranscriptomicsIdentification of genes responsive to mild hyperthermia in human normal fibroblast OUMS-36 cells
Hyperthermia is widely used to treat patients with various cancers. Here, the effects of heat stress at 41M-BM-0C for 30 min (mild hyperthermia) on the gene expression in OUMS-36 human normal fibroblast cells were investigated using an Affymetrix GeneChip system. The cells were treated with mild hyp...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-39178 | biostudies-arrayexpress
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