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ProteomicsHierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID
Large heteromeric multiprotein complexes play pivotal roles at every step of gene expression in eukaryotic cells. Among them, the 20-subunits basal transcription factor TFIID nucleates RNA polymerase II preinitiation complex at gene promoters. Here, by combining systematic RNA-immunoprecipitation ex...
ORGANISM(S): Homo sapiens (Human) 
2023-07-04 | PXD036358 | Pride
Taf1-dependent co-translational assembly of tfiid 
UnknownHierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID.
Not available
S-EPMC10104070 | biostudies-literature
UnknownHierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID.
Not available
S-EPMC10442232 | biostudies-literature
TranscriptomicsTranslational co-culture model reveals epithelial-mesenchymal mechanisms of lung fibrosis and identifies NF-κB as potential therapeutic target
The interaction of lung epithelial and lung mesenchymal cells was investigated in a novel co-culture model of human pulmonary fibrosis. Remarkably, co-culturing both cell types induced cell-type-specific responses, including fibroblast-to-myofibroblast differentiation and epithelial-to-mesenchymal t...
ORGANISM(S): Homo sapiens 
2022-10-03 | E-MTAB-11847 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of PAPS1-dependent polyadenylation identifies novel roles for functionally specialized poly(A) polymerases in Arabidopsis thaliana
The poly(A) tail at 3' ends of eukaryotic mRNAs promotes their nuclear export, stability and translational efficiency, and changes in its length can strongly impact gene expression. The Arabidopsis thaliana genome encodes three canonical nuclear poly(A) polymerases, PAPS1, PAPS2 and PAPS4. As shown ...
ORGANISM(S): Arabidopsis thaliana 
2015-07-30 | E-GEOD-57690 | biostudies-arrayexpress
TranscriptomicsLooking for mitochondrial associated RNA
We investigated the peripheral mitochondrial localization of nuclear-encoded mRNAs (MLR) in various conditions in which translation was inhibited or the mRNA binding protein context altered (Delta puf3). We used cell fractionation protocols together with microarray to assess the distribution of mRNA...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-01 | E-GEOD-9393 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel isoforms of Huntingtin reveals a new hominid-specific exon
Huntington’s disease (HD) is a devastating neurological disorder that is caused by an expansion of the poly-Q tract in exon 1 of the Huntingtin gene (HTT). HTT is an evolutionarily conserved and ubiquitously expressed protein that has been linked to a variety of functions including transcriptional r...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-66769 | biostudies-arrayexpress
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