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TranscriptomicsGenome-wide analysis of gene transcription in myocardium of the doxycycline inducible Tafazzin shRNA knockdown mouse model of Barth syndrome
Analysis of the transcriptome of cardiac tissue from mice trangenically engineered with a doxycycline inducible Tafazzin shRNA knockdown to mimic the loss of function of Tafazzin in Barth syndrome. ShRNA induced knockdown mice were compared to wildtype littermates also fed the doxycyline diet. The...
ORGANISM(S): Mus musculus 
2011-11-05 | E-GEOD-33452 | biostudies-arrayexpress
GenomicsTafazzin-Deficient Zebrafish Display Mitochondrial Dysfunction and Metabolic Defects Without Myopathy
Tafazzin-Deficient Zebrafish Display Mitochondrial Dysfunction and Metabolic Defects Without Myopathy
PRJNA1194115 | ENA
GenomicsTafazzin Regulates Cell State by Modulating Phosphatidylethanolamine and Phosphatidylserine levels
Tafazzin Regulates Cell State by Modulating Phosphatidylethanolamine and Phosphatidylserine levels
PRJNA418909 | ENA
TranscriptomicsTafazzin-Deficient Zebrafish Display Mitochondrial Dysfunction and Metabolic Defects Without Myopathy
Barth syndrome is a rare X-linked syndrome characterized by cardiomyopathy, skeletal myopathy, and neutropenia. This life-threatening disorder results from loss of function mutations in TAFAZZIN, which encodes a phospholipid-lysophospholipid transacylase located in the mitochondria inner membrane. D...
ORGANISM(S): Danio rerio 
2025-07-03 | GSE283499 | GEO
GenomicsReduced basal insulin secretion from islets isolated from tafazzin deficient mice is associated with reduced mitochondrial function
Reduced basal insulin secretion from islets isolated from tafazzin deficient mice is associated with reduced mitochondrial function
PRJNA561720 | ENA
TranscriptomicsTafazzin Regulates Cell State by Modulating Phosphatidylethanolamine and Phosphatidylserine levels
Inhibiting tafazzin a cardiolipin remodeling enzyme reduces stemness of AML by modulating the level of phosphatidylserine
ORGANISM(S): Homo sapiens 
2019-03-28 | GSE107045 | GEO
TranscriptomicsReduced basal insulin secretion from islets isolated from tafazzin deficient mice is associated with reduced mitochondrial function
Tafazzin is a transacylase which causes the content and molecular structure of cardiolipin (CL) to be altered in the inner mitochondrial membrane. The enzymatic machinery responsible for oxidative respiration are localized to the inner mitochondrial membrane and require CL for activity. As a result,...
ORGANISM(S): Mus musculus 
2021-07-31 | GSE136242 | GEO
UnknownBarth syndrome mutations that cause tafazzin complex lability.
Not available
S-EPMC3101092 | biostudies-literature
UnknownPhenotypic Characterization of Female Carrier Mice Heterozygous for Tafazzin Deletion.
Not available
S-EPMC10525480 | biostudies-literature
UnknownTafazzin regulates neutrophil maturation and inflammatory response.
Not available
S-EPMC11933368 | biostudies-literature
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