Sort   by:  
 Page size 
TranscriptomicsDevelopment of gene expression signatures for TLX1 overexpression in human thymus C34+ T-cell progenitors cultured on an OP9-DLL1 feeder layer
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62143 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures with lncRNAs for T-cell subsets (CD34+ and CD4+CD8+)
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-61873 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures with lncRNAs for coculture of CD34+ T-cells with an OP9-DLL1 feeder layer
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-61871 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of CD34+ thymocytes that were cultured on an OP9-GFP or OP9-DLL1 feeder layer.
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-62000 | biostudies-arrayexpress
GenomicsDistinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development [BCL11B_coculture]
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development [BCL11B_coculture]
PRJNA533188 | ENA
GenomicsDistinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development [BCL11B_ex vivo]
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development [BCL11B_ex vivo]
PRJNA533187 | ENA
GenomicsDistinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development [miRNA BCL11B_coculture]
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development [miRNA BCL11B_coculture]
PRJNA533190 | ENA
GenomicsDistinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development [miRNA BCL11B_ex vivo]
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development [miRNA BCL11B_ex vivo]
PRJNA533189 | ENA
GenomicsGATA3 restrains Notch signaling activity and represses NK cell development to induce human T cell commitment following Notch-induced T-lineage specification (ChIP-Seq)
The stepwise conversion of multipotent precursors into committed T-cell progenitors depends on several transcriptional regulators, but the interplay between these factors is still obscure. This is particularly true in human since the core early Notch signalling pathway also supports NK cell developm...
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-71751 | biostudies-arrayexpress
GenomicsDistinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development
PRJNA533059 | ENA
Sort   by:  
 Page size