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TranscriptomicsTranscription profiling of mouse AC61 cells were derived from a C-cell adenocarcinoma developed in Rb+/-N-ras-/- mouse transfected with pRb to identify genes that are regulated by pRb in AC61 cells
This experiment is to identify genes that are regulated by pRb in AC61 cells. AC61 cells were derived from a C-cell adenocarcinoma developed in an Rb+/-N-ras-/- mouse. Experiment Overall Design: AC61 cells were infected with retrovirus derived from pLXSB or pLSXB-Rb and selected with balsticidin fo...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-12637 | biostudies-arrayexpress
TranscriptomicsATM mediates pRB function to control DNMT1 protein stability and DNA methylation
The retinoblastoma tumor suppressor gene (RB) product has been implicated in epigenetic control of gene expression owing to its ability to physically bind to many of chromatin modifiers. However, the biological and clinical significance of this activity was not well elucidated. To address this, we p...
ORGANISM(S): Mus musculus 
2013-05-31 | E-GEOD-47501 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene sets after deleting Rb in p53 null background primary prostate cells [Rb only]
Our findings suggested that cytokines were upregulated in p53 null primary prostate cells after deleting Rb. Rb deletion is important for prostate cancer progression. p53-/- Rbf/f vs p53-/- Rb∆f/∆f primary prostate cells.Three independent experiments were performed.
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-68903 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene sets after deleting Rb and Pten in p53 null background primary prostate cells [Rb and Pten]
Our findings suggested that cytokines were upregulated in p53 null primary prostate cells after deleting Rb and/or Pten. Rb and Pten deletion are important for prostate cancer progression. p53-/- Rbf/f vs p53-/- Rb∆f/∆f primary prostate cells. Three independent experiments were performed. p53-/...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-68904 | biostudies-arrayexpress
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