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ProteomicsSKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes
Polycomb group (PcG) proteins are evolutionarily conserved repressors of developmental genes. Paradoxically, the same PcG proteins also play roles in gene activation via mechanisms that are not yet fully understood. Here, to reveal the function of S-phase kinase-associated protein 1A (SKP1A), an ess...
ORGANISM(S): Mus Musculus (mouse) 
2025-08-27 | PXD047552 | JPOST Repository
ProteomicsSKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes
Polycomb group (PcG) proteins are evolutionarily conserved repressors of developmental genes. Paradoxically, the same PcG proteins also play roles in gene activation via mechanisms that are not yet fully understood. Here, to reveal the function of S-phase kinase-associated protein 1A (SKP1A), an ess...
ORGANISM(S): Mus Musculus (mouse) 
2025-08-27 | PXD047556 | JPOST Repository
ProteomicsPCGF1-PRC1 safeguards recovery of nucleosome positioning during S-phase to ensure early hematopoiesis
Polycomb repressive complexes 1 and 2 (PRC1 and 2) repress lineage inappropriate genes during development to maintain proper cellular identities. To reveal the function of a variant PRC1 containing PCGF1 (PCGF1-PRC1), we prepared PCGF1 interacting proteins by immunoprecipitation and characterized th...
ORGANISM(S): Mus Musculus (mouse) 
2023-05-13 | PXD033883 | JPOST Repository
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