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UnknownInhibition of HDAC and Signal Transduction Pathways Induces Tight Junctions and Promotes Differentiation in p63-Positive Salivary Duct Adenocarcinoma.
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S-EPMC9179926 | biostudies-literature
TranscriptomicsProtective efficacy of orally administered, heat-killed Lactobacillus pentosus b240 against influenza A virus
Influenza A(H1N1)pdm virus caused the first human pandemic of the 21st century. Although various probiotic Lactobacillus species have been shown to have anti-microbial effects against pneumonia-inducing pathogens, the prophylactic efficacy and mechanisms behind their protection remain largely unknow...
ORGANISM(S): Mus musculus 
2013-03-29 | E-GEOD-43764 | biostudies-arrayexpress
TranscriptomicsDifferences in cytokine production in human macrophages and in virulence in mice are attributable to the PA protein of H5N1 influenza viruses
Background. The pathogenesis of influenza A virus subtype H5N1 (hearafter, "H5N1") infection in humans is not completely understood, although hypercytokinemia is thought to play a role. We previously reported that most H5N1 viruses induce high cytokine responses in human macrophages, where...
ORGANISM(S): Homo sapiens 
2012-09-30 | E-GEOD-40711 | biostudies-arrayexpress
TranscriptomicsDisease severity is associated with differential gene expression at the early and late phases of infection in non-human primates infected with different H5N1 highly pathogenic avian influenza viruses
Occasional transmission of highly pathogenic avian H5N1 influenza viruses to humans causes severe pneumonia with high mortality. To better understand the mechanisms via which H5N1 viruses induce severe disease in humans, we infected cynomolgus macaques with six different H5N1 strains isolated from h...
ORGANISM(S): Macaca mulatta 
2014-05-27 | E-GEOD-57970 | biostudies-arrayexpress
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