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GenomicsGenome wide analysis of AR binding sites and histone modifications in prostate cancer
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation.We performed ChIP-seq analysis to investigate the role of AR and histone modifications.In addition, by siRNA mediated knockdown of AR-associated factors, changes of AR-binding sit...
ORGANISM(S): Homo sapiens 
2015-02-08 | E-GEOD-62492 | biostudies-arrayexpress
GenomicsGenome wide mapping of PSF binding sites in prostate cancer cells
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. We identified androgen-regulated long non-coding RNA, CTBP1-AS, located in the antisese region of CTBP1 gene. CTBP1-AS activate AR signaling by epigenetically repress AR-associat...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-45124 | biostudies-arrayexpress
TranscriptomicsEpithelium-only cultured stem cells isolated from human pluripotent stem cell derived intestinal organoids grown in matrigel and alginate
Human intestinal organoids were grown in a typical 3D matrigel culture environment, or in an alginate gel, then a subset from each condition were xenotransplanted to vascularized and mature in vivo. Epithelium was isolated and epithelial only organoids (enteroids) were then grown from each condition...
ORGANISM(S): Homo sapiens 
2019-06-27 | E-MTAB-7000 | biostudies-arrayexpress
TranscriptomicsCulture media-induced transcriptional variation in lung cancer (A549), colorectal cancer (HCT116), ovarium cancer (SKOV3) and glioblastoma (U87MG) spheroids
Spheroids, near spherical multicellular aggregates, are one of the most common types of threedimensional (3D) cell cultures. Despite decades of implementation of spheroid technology in various fields of life science and medical research, no minimal information (MI) guidelines are available to cope w...
ORGANISM(S): Homo sapiens 
2021-10-01 | E-MTAB-10862 | biostudies-arrayexpress
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