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ProteomicsIdentification of gravity-responsive proteins in mouse soleus muscle using proteomic analysis
This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in space flight-induced osteopenia as well as ...
ORGANISM(S): Mus Musculus (mouse) 
2023-09-19 | PXD041190 | JPOST Repository
ProteomicsUse of data-independent acquisition mass spectrometry to identify an objective serum indicator of the need for osteoporotic therapeutic intervention
Osteoporosis is characterized by weakened bone microstructure and loss of bone mass. Current diagnostic criteria for osteoporosis are based on the T-score, which is a measure of bone mineral density. However, osteoporotic fragility fractures can occur regardless of the T-score, underscoring the need...
ORGANISM(S): Homo Sapiens (human) 
2024-04-10 | PXD041546 | JPOST Repository
ProteomicsComprehensive human serum spectral library
For a comprehensive analysis of the human serum proteome, we constructed a spectral library for DIA-MS. Our spectral library contained information on 20,303 peptides derived from 1,597 human serum proteins. We believe that the constructed spectral library will be useful for proteomic analysis of hum...
ORGANISM(S): Homo Sapiens (human) 
2024-04-10 | PXD041558 | JPOST Repository
ProteomicsChanges in the astronaut serum proteome during prolonged spaceflight
The molecular mechanisms associated with spaceflight-induced biological adaptations that may affect many healthy tissue functions remain poorly understood. In this study, we analyzed temporal changes in the serum proteome of six astronauts during prolonged spaceflight missions using quantitative com...
ORGANISM(S): Homo Sapiens (human) 
2024-01-22 | PXD044609 | JPOST Repository
ProteomicsIdentification of serum prognostic biomarkers of severe COVID-19 using a quantitative proteomic approach
The COVID-19 pandemic is an unprecedented threat to humanity that has provoked global health concerns. Since the etiopathogenesis of this illness is not fully characterized, the prognostic factors enabling treatment decisions have not been well documented. Accurately predicting the progression of th...
ORGANISM(S): Homo Sapiens (human) 
2021-11-02 | PXD021702 | JPOST Repository
ProteomicsHuman serum spectral library for DIA mass spectrometry
For comprehensive human serum proteome analysis, we attempted to construct a serum spectral library for DIA-MS. Consequently, the customized spectral DIA library contained information on 23,196 peptides derived from 1,534 human serum proteins. We expect that this customized spectral DIA library will...
ORGANISM(S): Homo Sapiens (human) 
2021-11-10 | PXD027635 | JPOST Repository
ProteomicsOsterix propionylated peptide identification
Propionylated peptides derived from over-expressed HA-tagged osterix in HEK293T cells were identified.
ORGANISM(S): Mus Musculus (mouse) 
2018-11-05 | PXD009147 | JPOST Repository
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