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ProteomicsLysosomal alterations and altered electrophysiological activity in atypical juvenile neuronal ceroid lipofuscinoses (CLN3 1 kb deletion, E295K) patient-derived cortical neurons
Juvenile neuronal ceroid lipofuscinoses (JNCL) is a lysosomal storage disorder associated with fatal neurodegeneration that is caused by mutations in CLN3. Most individuals with JNCL carry at least one allele with 1 kb deletion in CLN3 which results in the deletion of exons 7 and 8. There is a need ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-07 | PXD032191 | Pride
Lysosomal storage disorder Neurological disease models Juvenile neuronal ceroid lipofuscinoses Human induced pluripotent stem cells 
TranscriptomicsSEA BREAM PATH_INTEST
To determine the effects on the intestine gene expression of pathogen exposure to Enteromyxum leei. One fish group was exposed to E. leei-contaminated effluent (recipient group = R) . R fish (n= 66, average weight = 134 g) were placed in two replicated 200L fibre-glass tanks which were set to receiv...
ORGANISM(S): Sparus aurata 
2010-06-05 | E-GEOD-19646 | biostudies-arrayexpress
UnknownRandomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer.
Not available
S-EPMC5321098 | biostudies-literature
TranscriptomicsAquafirst_seabream_pathogen exposure_head kidney
To determine the effects of pathogen exposure to Enteromyxum leei on head kidney gene expression. Keywords: confinement, cortisol, stress response, time course, microarray 30 head kidney samples - Thirty slides were hybridised using a reference design. Three groups (control, infected and non-infect...
ORGANISM(S): Sparus aurata 
2010-02-28 | E-GEOD-18219 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Atlantic salmon cell line SHK-1 exposed to interferon type 1 and interferon gamma for 6 or 24 hours
We have stimulated an Atlantic salmon cell line, SHK-1, with both type I and type II recombinant salmonid IFNs and analysed the transcriptional response by microarray analysis. Cells were exposed to recombinant IFNs for 6 or 24 h or were left unexposed as controls. RNA was hybridised to a 17k feat...
ORGANISM(S): Salmo salar 
2007-10-08 | E-MEXP-1023 | biostudies-arrayexpress
Transcriptomicspamknight ovine abomasum1
To address the protective mechanisms generated in animals on previous exposure to this parasite, using samples of abomasal mucosa collected pre- and post- challenge from animals of differing immune status in an experimental model of Teladorsagia circumcincta infection.
ORGANISM(S): Ovis aries 
2011-05-20 | E-TABM-1149 | biostudies-arrayexpress
Transcriptomicspamknight ovine abomasum
To address the protective mechanisms generated in animals on previous exposure to this parasite, using samples of abomasal mucosa collected pre- and post- challenge from animals of differing immune status in an experimental model of T. circumcincta infection.
ORGANISM(S): Ovis aries 
2011-05-20 | E-TABM-1150 | biostudies-arrayexpress
UnknownCross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike.
Not available
S-EPMC7524645 | biostudies-literature
TranscriptomicsRNA-seq of human breast cancer cell lines MCF7 and T74D naive and resistant to palbociclib treated with capivasertib, fulvestrant and combination
T47D and MCF7 cell lines were treated with long-term (continuous) palbociclib to induce 4 resistant cell-lines (T47D RB-, T47D CDK6H, MCF7 RB- and MCF7 PacqR). Each cell line (both parental and resistant) were then treated with DMSO (control), capivasertib monotherapy, fulvestrant monotherapy and ca...
ORGANISM(S): Homo sapiens 
2023-08-14 | E-MTAB-13262 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing of Ovis aries
We have completed the high quality reference genome for domestic sheep (Oar v3.1) and performed a detailed survey of gene expression across different tissues. RNA-seq data of 7 tissue types from the reference female Texel and skin tissue from a Gansu alpine fine wool sheep were sequenced. Here is t...
ORGANISM(S): Ovis aries 
2014-06-06 | E-GEOD-56643 | biostudies-arrayexpress
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