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TranscriptomicsGenome-wide specificity of genome editing by both CRISPR-Cas9 and TALEN in the model plant Physcomitrium patens
CRISPRs and TALENs are efficient systems for gene editing in many organisms including plants. In many cases the CRISPR-Cas or TALEN modules are expressed in the plant cell only transiently. Theoretically, transient expression of the editing modules should limit unexpected effects compared to stable ...
ORGANISM(S): Physcomitrium patens 
2022-03-03 | E-MTAB-11497 | biostudies-arrayexpress
GenomicsIllumina HiSeq next -generation sequencing of telomere fusion amplicons purified from crisis-stage MCR5HPVE6E7 and TALEN-transfected HCT116 cell lines at 48 and 120 hours post-transfection.
We sequenced and characterised inter-chromosomal and intra-chromosomal telomere fusions amplified from crisis-stage MCR5HPVE6E7 fibroblasts and DNA repair-compromised HCT116 cell lines nucleofected with plasmids encoding TALEN pairs to induce targeted cleavage at the 17p telomere.
ORGANISM(S): Homo sapiens 
2016-02-24 | E-MTAB-3811 | biostudies-arrayexpress
Genomicssynthetic construct
TALEN in vitro selection libraries
PRJNA233644 | ENA
GenomicsT-CAST: An optimized CAST-Seq pipeline for TALEN reveals superior safety and efficacy of obligate-heterodimeric scaffolds
T-CAST: An optimized CAST-Seq pipeline for TALEN reveals superior safety and efficacy of obligate-heterodimeric scaffolds
PRJNA923337 | ENA
GenomicsPhaeodactylum tricornutum (strain4) knockouts
Pt4 Lhcx1 knockout using TALEN
PRJEB33825 | ENA
UnknownComparison of TALEN scaffolds in Xenopus tropicalis.
Not available
S-EPMC3863421 | biostudies-literature
TranscriptomicsTALEN-mediated MeCP2 Gene Mutagenesis in Rhesus and Cynomolgus Monkeys
We report Transcription Activator-like Effector Nucleases (TALEN)-mediated mutagenesis of the Rett Syndrome gene, methyl-CpG binding protein 2 (Mecp2), in nonhuman primates (NHPs). Microinjection of Mecp2-targeting TALEN plasmids into rhesus and cynomolgus zygotes caused 40-50% of the embryos harbor...
ORGANISM(S): Macaca mulatta 
2016-12-31 | GSE53434 | GEO
OtherT-CAST: An optimized CAST-Seq pipeline for TALEN reveals superior safety and efficacy of obligate-heterodimeric scaffolds
Transcription activator-like effector nucleases (TALENs) are programmable nucleases that have entered the clinical stage. Each subunit of the dimer consists of a DNA-binding domain composed of an array of TALE repeats fused to the catalytically active portion of the FokI endonuclease. Upon DNA-bindi...
ORGANISM(S): Homo sapiens 
2023-05-05 | GSE222763 | GEO
UnknownE-TALEN: a web tool to design TALENs for genome engineering.
Not available
S-EPMC3814377 | biostudies-literature
UnknownHighly efficient genome editing via 2A-coupled co-expression of two TALEN monomers.
Not available
S-EPMC4167141 | biostudies-literature
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