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TranscriptomicsSBV - Gene Expression Profiles of Lung Cancer Tumors - Adenocarcinomas and Squamous Cell Carcinomas
This dataset encompassing the profiles of 150 lung cancer tumors was developed to serve as test dataset in the SBV IMPROVER Diagnostic Signature Challenge (sbvimprover.com). The aim of this subchallenge was to verify that it is possible to extract a robust diagnostic signature from gene expression d...
ORGANISM(S): Homo sapiens 
2013-10-18 | E-GEOD-43580 | biostudies-arrayexpress
TranscriptomicsNasal gene expression in smokers, former smokers, and COPD subjects
Samples were derived from the non-interventional, observational, case-control study conducted in the UK. The study has been registered on ClinicalTrials.gov with identifier NCT01780298.
ORGANISM(S): Homo sapiens 
2015-06-30 | E-MTAB-4015 | biostudies-arrayexpress
TranscriptomicsThe impact of long term cigarette smoke, but not Tobacco Heating System 2.2 exposure on the genes involved in cardiac muscle structure and function in Apoe-/- mouse.
Cigarette smoking is a major risk factor for the development and progression of diseases such as cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD). Modified risk tobacco products (MRTP) are designed to reduce smoking-related health risks. Suitable animal models are import...
ORGANISM(S): Mus musculus 
2017-02-27 | E-MTAB-3900 | biostudies-arrayexpress
TranscriptomicsCell Proliferation Network Perturbation Measured in NHBE cells
Modern M-^QomicsM-^R technologies, where changes in the expression of thousands of molecular species can be investigated in even a simple experiment, provide contemporary biomedical researchers with an unprecedented level of molecular granularity. An outstanding challenge is transformation of this ...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-MTAB-1272 | biostudies-arrayexpress
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
TranscriptomicsBiological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
We compared early biological changes in mice after inhalation exposures to cigarette smoke or e-vapor aerosols (MarkTen® cartridge with Carrier, Test-1, or Test-2 formulations; 4% nicotine). Female C57BL/6 mice were exposed to 3R4F cigarette smoke or e-vapor aerosols by nose-only inhalation for up t...
ORGANISM(S): Mus musculus 
2021-02-28 | E-MTAB-10166 | biostudies-arrayexpress
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