Tamoxifen - OmicsDI

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CHEBI ID

CHEBI:15891 (13)
CHEBI:41774 (11)
CHEBI:15428 (10)
CHEBI:30769 (10)
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CHEBI:16467 (9)
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CHEBI:17012 (8)
CHEBI:16737 (8)
CHEBI:17295 (8)
CHEBI:32389 (7)
CHEBI:28997 (7)
CHEBI:16893 (7)
CHEBI:16691 (7)
CHEBI:17033 (7)
CHEBI:16424 (7)

Metabolite Name

Tamoxifen (60)
Adenosine (45)
Oleamide (41)
Creatinine (40)
Creatine (40)
Betaine (39)
Phytosphingosine (39)
Choline (36)
Glycerophosphocholine (36)
Guanine (35)
Hypoxanthine (35)
Sphingosine (34)
Sphinganine (34)
Riboflavin (34)
Adenine (34)
Uracil (33)
Spermidine (33)
Cytosine (33)
Niacinamide (32)
L-Phenylalanine (32)
N6,N6,N6-Trimethyl-L-lysine (31)
L-Proline (31)
Pyridoxine (31)
L-Histidine (31)
L-Arginine (30)
Serotonin (30)
Cytidine (30)
Cholesterol (29)
Taurine (29)
Tyramine (29)

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2020 (165)
2019 (119)
2018 (110)
2017 (96)
2015 (56)
2016 (55)
2013 (19)
2011 (2)

Modelling Approach

Differential equation model (1)

Study status

Not yet recruiting (1)
Completed (1)

Lab affiliation

CECAD Excellence Center, University of Cologne, Germany, D-50931 Center for Physiology and Pathophysiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany, D-50931 (2)
Inserm U1016, Institut Cochin, 24 rue du Faubourg Saint-Jacques, 75014 PARIS, FRANCE. (2)
Mass Spectrometry/Proteomics Facility, Netherlands Cancer Institute, Amsterdam, Netherlands. (2)
Medical Oncology (2)
Molekulare Genomanalyse (B050) Deutsches Krebsforschungszentrum Im Neuenheimer Feld 580 69120 Heidelberg Germany (2)
Affiliated Cancer Hospital of Chongqing University (1)
Associate Professor, Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Department of Pharmacology and Cancer Biology Duke University Medical Center (1)
Barbara M. Braunger, Institute of Neuroanatomy, University Clinic Hamburg-Eppendorf, Hamburg, Germany (1)
Biological Mass Spectrometry Lab Department of Translational Medicine (DiMeT) Center for Translational Research on Autoimmune & Allergic Diseases - CAAD University of Piemonte Orientale Corso Trieste 15/A, 28100, Novara, Italy (1)
Cecad Research Center Cologne/Department of Translational Genomics, Cologne University medical center, Cologne, Germany (1)
Centre for Cancer Cell & Molecular Biology Barts Cancer Institute, Queen Mary University of London Charterhouse Square London EC1M 6BQ U.K. (1)
Centre for Gene Regulation and Expression University of Dundee (1)
Centre for Genomics and Computational Biology Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ Tel: +44 (0)20 7882 8266 | Fax: +44 (0)20 7882 3891 | Email: p.cutillas@qmul.ac.uk (1)
Centre for Heamato-Oncology / Barts Cancer Institute (1)
Centre for Regenerative Medicine (CRM), Institute for Regeneration and Repair (IRR), University of Edinburgh (1)
Charles Perkins Centre, School of Medical Sciences, University of Sydney, Sydney, Australia. (1)
DKFZ - German Cancer Research Center, “Division of Virus-Associated Carcinogenesis”, Im NeuenheimerFeld 280, 69120 Heidelberg, Germany (1)
Department of Cancer Sciences, Cleveland Clinic, 9500 Euclid Avenue, NE60, Cleveland, OH, 44195, USA. (1)
Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, DK-5000 Odense C, Denmark (1)
Department of Chemistry, Duke University Durham, North Carolina (1)
Department of Chemistry, Duke University Durham, North Carolina (1)
Department of Laboratory Medicine and Pathology Mayo Clinic, Rochester, Minnesota 55905 United States (1)
Department of Orthopaedic Surgery School of Medicine University of California San Diego 9500 Gilman Drive MC0863 La Jolla, CA, USA (1)
Department of Pediatrics, Department of Cell Biology, Neurobiology and Anatomy Medical College of Wisconsin, Milwaukee, WI, United States (1)
Department of medical Oncology Laboratory of translational breast cancer genomics and proteomics (1)
Director of Women’s Health Research Women’s Service Line Inova Health System (1)
Discovery Proteomics Facility, University of Oxford (1)
Division of Endocrinology, Metabolism & Lipid Research, Washington University, St. Louis Department of Cell Biology & Physiology, Washington University, St. Louis (1)
Federal Center of Brain Research and Neurotechnologies, Federal Medico-Biological Agency, 117513 Moscow, Russia (1)
Fraunhofer Institute for Molecular Biology and Applied Ecology IME Auf dem Aberg 1 | 57392 Schmallenberg | Germany (1)

Keyword

Tamoxifen (1)
Zoledronic Acid (1)
Anastrozole (1)
Goserelin (1)
Zoledronate (1)
Austrian Breast & Colorectal Cancer Study Group (ABCSG) (1)
12 (1)
Hormone receptor-positive (1)
Stage I (1)
Bone mineral density (1)
BMD (1)
Bisphosphonate (1)
Stage II (1)
Premenopausal (1)
Phase 3 (1)

IsPrivate

False (2)

Modification

2x(15)N labeled L-lysine (2)
4x(15)N labeled L-arginine (2)
-17.026549 (1)
15.994915 (1)
42.010565 (1)

Study type

Transcription profiling by array (832)
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Unknown experiment type (40)
ChIP-chip by tiling array (33)
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RNA-seq of coding RNA from single cells (24)
Other (16)
Methylation profiling by array (13)
Animal - High-throughput sequencing (10)
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Animal - Single-cell sequencing (3)
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Release Date

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2012 (269)
2013 (268)
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2009 (98)
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2006 (15)
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2003 (3)
1999 (2)
2002 (1)
2000 (1)

Location

Germany (1)
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Metabolomic Profiling Reveals Key Metabolic Alterations in MCF7 Tamoxifen-Resistant Cells Following EPAS1 Inhibition

This study aims to investigate the metabolic alterations associated with acquired tamoxifen (TAM) resistance in luminal A breast cancer cells. Using untargeted LC-MS/MS metabolomics, we compared parental MCF7 and TAM-resistant MCF7/Tam1 cells to identify key metabolic pathways affected by EPAS1 (...

2025-07-04 | MTBLS12677 | MetaboLights

Mass spectroscopy‑based proteomics and metabolomics analysis of triple‑positive breast cancer cells treated with tamoxifen

Not available

ORGANISM(S): Homo sapiens

ST002317 | MetabolomicsWorkbench

Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver

Tamoxifen is a non-steroidal anti-estrogenic drug widely used for the treatment and prevention of breast cancer in women; however, there is evidence that tamoxifen is hepatocarcinogenic in rats, but not in mice. Additionally, it has been reported that tamoxifen may cause non-alcoholic fatty liver di...

ORGANISM(S): Mus musculus

2014-10-11 | E-GEOD-62267 | biostudies-arrayexpress

Integrative Analyses of Gene Expression and DNA Methylation Profiles in a Breast Cancer Cell Line Model of Tamoxifen-Resistance Indicate a Crucial Role of Cells with Stem-like Properties

Purpose: Development of resistance to tamoxifen is an important clinical issue in the treatment of patients with breast cancer. Tamoxifen resistance may be the result of the acquisition of epigenetic regulation such as DNA methylation within breast cancer cells resulting in changed mRNA expression o...

ORGANISM(S): Homo sapiens

2014-02-03 | E-GEOD-40665 | biostudies-arrayexpress

CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AHR signaling

Targeting the estrogen signaling pathway has proved to be of great value in the treatment of human breast cancer. Tamoxifen, a selective estrogen receptor modulator (SERM), is the most widely used antiestrogen. However, only 40-50% of patients with estrogen receptor (ER) positive breast cancer benef...

ORGANISM(S): Homo sapiens

2012-12-21 | E-GEOD-31831 | biostudies-arrayexpress

Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer

Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with ER-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may well be expressed in a dynamic manner. In this study we assessed ge...

ORGANISM(S): Homo sapiens

2010-06-17 | E-GEOD-22386 | biostudies-arrayexpress

Tamoxifen treatment of MCF-7 breast cancer cells

Tamoxifen is an anti-estrogen drug used in the treatment of Estrogen Receptor (ER) positive breast cancer. Effects and side effects of tamoxifen is the sum of tamoxifen and all its metabolites. Using concentrations that mimic the clinical situation we examined effects of 4OHtam, 4OHNDtam and NDtam o...

ORGANISM(S): Homo sapiens

2014-10-24 | E-MTAB-2729 | biostudies-arrayexpress

Tamoxifen-resistant human breast cancer cell lines

A functional genetic screen to identify genes causing tamoxifen resistance in an estrogen-dependent human breast cancer cell model was performed. By insertion of defective retrovirus into the genome, individual genetic changes were introduced at random in ZR-75-1 cells. Subsequently, infected cells ...

ORGANISM(S): Homo sapiens

2009-12-09 | E-GEOD-14513 | biostudies-arrayexpress

Mass spectroscopy‑based proteomics and metabolomics analysis of triple‑positive breast cancer cells treated with tamoxifen and trastuzumab

Not available

ORGANISM(S): Homo sapiens

ST002319 | MetabolomicsWorkbench

Novel estrogen and tamoxifen induced genes

The breast cancer promoting effects of estrogen and the chemopreventive effects of tamoxifen are thought to be mediated by the estrogen receptor, a ligand-dependent transcription factor. Therefore, comprehensive analysis of gene expression profiles following estrogen or tamoxifen treatment may help ...

ORGANISM(S): Homo sapiens

2003-07-16 | E-GEOD-507 | biostudies-arrayexpress

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