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TranscriptomicsDown-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients
MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators. Aberrant microRNA expression has been described for several human malignancies, and this new class of small regulatory RNAs has both oncogenic and tumor suppressor functions. Despite th...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-14772 | biostudies-arrayexpress
TranscriptomicsThe Chimeric Oncoprotein TLS-CHOP Represses Expression of the Anticancer Cytokine MDA-7/IL-24 in Myxoid Liposarcoma Cells
The TLS-CHOP fusion protein is found in the majority of human myxoid liposarcomas (MLS), and is thought to have oncogenic functions. Until now, however, the molecular function of TLS-CHOP for oncogenesis is still elusive. In this report, we have revealed that knockdown of TLS-CHOP by specific siRN...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-33616 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of serous ovarian cancer samples
To elucidate the mechanisms of rapid progression of serous ovarian cancer, gene expression profiles from forty-three ovarian cancer tissues comprising eight early stage and thirty-five advanced stage tissues were performed using oligonucleotide microarrays of 18,716 genes. By non-negative matrix fac...
ORGANISM(S): Homo sapiens 
2009-07-19 | E-GEOD-12470 | biostudies-arrayexpress
TranscriptomicsImmune-activation as a therapeutic direction for patients with high-risk ovarian cancer based on gene expression signature (2)
Advanced-stage ovarian cancer is one of the most lethal gynecologic malignancies. To improve prognosis of patients with ovarian cancers, a predictive biomarkers leading to personalized treatments are required. In this large-scale cross-platform study of six microarray datasets consisting of 1054 ova...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-32063 | biostudies-arrayexpress
TranscriptomicsImmune-activation as a therapeutic direction for patients with high-risk ovarian cancer based on gene expression signature (1)
The Japanese Serous Ovarian Cancer Study Group Advanced-stage ovarian cancer is one of the most lethal gynecologic malignancies. To improve prognosis of patients with ovarian cancers, a predictive biomarkers leading to personalized treatments are required. In this large-scale cross-platform study of...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-32062 | biostudies-arrayexpress
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