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MetabolomicsDiallyl disulfide (DADS) ameliorates intestinal Candida albicans infection by modulating the gut microbiota and metabolites and providing intestinal protection in mice
Diallyl disulfide (DADS), a garlic extract also known as allicin, has been reported to have numerous biological activities, including anticancer, antifungal, and inflammation-inhibiting activities, among others. Although many studies have assessed whether DADS can treat Candida albicans infec...
2022-05-03 | MTBLS3750 | MetaboLights
MetabolomicsAlterations in the gut microbiota and metabolic profiles coincide with intestinal damage in mice with a bloodborne Candida albicans infection
Candida albicans is an opportunistic fungus that can threaten life especially in patients with candidemia. The morbidity and mortality of candidemia originating from a central venous catheter (CVC) and illicit intravenous drug use (IVDU) are increasing. However, the mechanism underlying the bloodbor...
2021-04-13 | MTBLS1918 | MetaboLights
UnknownEGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL.
Not available
S-EPMC10823730 | biostudies-literature
UnknownMachine learning integration of multi-modal analytical data for distinguishing abnormal botanical drugs and its application in Guhong injection.
Not available
S-EPMC10759515 | biostudies-literature
UnknownChina National Medical Products Administration approval summary: anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy.
Not available
S-EPMC6585030 | biostudies-literature
UnknownLacticaseibacillus casei JS-2 from 'Jiangshui' Reduces Uric Acid and Modulates Gut Microbiota in Hyperuricemia.
Not available
S-EPMC11817023 | biostudies-literature
ProteomicsThe ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis
This study aimed to evaluate the therapeutic effect of ME against UC and to elucidate its underlying molecular mechanism and potential target. ME was semi-synthesized on a gram scale via a biomimetic route. Its activity was assessed in an LPS-induced RAW264.7 macrophage model in vitro and a DSS-indu...
ORGANISM(S): Mus Musculus 
2026-01-27 | PXD073619 |
MetabolomicsThe Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism
The overuse of antibiotics in animal agriculture and medicine has caused a series of potential threats to public health. Macleaya cordata is a medicinal plant species from the Papaveraceae family, providing a safe resource for the manufacture of antimicrobial feed additive for livestock. The active ...
2017-04-24 | MTBLS435 | MetaboLights
UnknownEvaluation of the therapeutic effects of QuickOpt optimization in Chinese patients with chronic heart failure treated by cardiac resynchronization.
Not available
S-EPMC5844885 | biostudies-literature
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