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ProteomicsHUWE1 Targets Mitochondria via RMC1 to Promote Neurodevelopment
The HECT-type E3 ubiquitin ligase HUWE1 is a critical regulator of protein homeostasis, genome stability, and neurodevelopment. Variants in HUWE1 are linked to X-linked intellectual disability (XLID), yet a significant number of HUWE1 variants are noncatalytic, leaving their disease mechanisms unres...
ORGANISM(S): Homo Sapiens 
2026-06-29 | PXD080345 |
ProteomicsSex-specific proteomic profiles and complement-C3-microglial axis drive depressive symptoms in Parkinson’s disease
In this study, hippocampal and cortical tissues were collected from mice and divided into four experimental groups: control (Con), traumatic brain injury (TBI), control with hydrogen sulfide treatment (Con + H₂S), and TBI with hydrogen sulfide treatment (TBI + H₂S). Each group included three biologi...
ORGANISM(S): Homo Sapiens 
2026-04-02 | PXD076542 |
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