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MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsIdentification of the interacting partner of FKBP10
we conducted immunoprecipitation (IP) in UMUC3 and T24 cells using FKBP10 and Flag antibodies, followed by mass spectrometry analysis.
ORGANISM(S): Homo Sapiens 
2024-07-20 | PXD054092 |
ProteomicsAcellular Nerve Perineurium Repairs Peripheral Nerve Injuries in a Rat Model via ECM-Mediated Barrier and Optimization of the Regenerative Microenvironment: Raw date of the proteomics analysis in this study
The project IPX0014571000 in iProX as an example dataset, which is composed of the raw data and analysis results of the study paper"Acellular Nerve Perineurium Repairs Peripheral Nerve Injuries in a Rat Model via ECM-Mediated Barrier and Optimization of the Regenerative Microenvironment".
ORGANISM(S): Rattus Norvegicus Canis Lupus Familiaris 
2025-12-17 | PXD071986 |
ProteomicsCyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome
Here we employed a non-enzymatic chemical labeling approach to introduce lactylation on lysine residues of model peptides and proteins. Tandem MS acquisition of lactylated peptide carriers on different MS platforms unequivocally led us to note an intense peak corresponding to the “cyclic” immonium ...
ORGANISM(S): Homo Sapiens 
2021-09-15 | PXD028488 |
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