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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
UnknownIntegrated Measurement for Early Detection (MIDO) as a digital strategy for timely assessment of non-communicable disease profiles and factors associated with unawareness and control: a retrospective observational study in primary healthcare facilities in Mexico.
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S-EPMC8413929 | biostudies-literature
UnknownExpanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events.
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S-EPMC10474064 | biostudies-literature
UnknownPre-emptive TIPS for the treatment of bleeding from gastric fundal varices: Results of a randomised controlled trial.
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S-EPMC10240269 | biostudies-literature
TranscriptomicsRNA-seq of primary human bone marrow derived mesenchymal stromal cells from pediatric B-cell acute lymphoblastic leukemia (B-ALL) patients
To investigate the identity of the tumor microenvironment in acute lymphoblastic leukemia (B-ALL), the transcriptome of mesenchymal stromal cells derived from bone marrow of three pediatric patients at the onset of the disease was analyzed and compared with its normal counterpart.
ORGANISM(S): Homo sapiens 
2021-10-16 | E-MTAB-10838 | biostudies-arrayexpress
UnknownHaplotype analysis of the internationally distributed BRCA1 c.3331_3334delCAAG founder mutation reveals a common ancestral origin in Iberia.
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S-EPMC7579869 | biostudies-literature
UnknownGRK2-Dependent HuR Phosphorylation Regulates HIF1α Activation under Hypoxia or Adrenergic Stress.
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S-EPMC7281538 | biostudies-literature
UnknownA PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response.
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S-EPMC10128431 | biostudies-literature
UnknownEffects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy.
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S-EPMC9028185 | biostudies-literature
UnknownSusceptibility patterns and molecular identification of Trichosporon species.
Not available
S-EPMC1251560 | biostudies-literature
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