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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
UnknownParvalbumin interneurons in the hippocampal formation of individuals with Alzheimer's disease: a neuropathological study of abnormal phosphorylated tau in neurons.
Not available
S-EPMC12018435 | biostudies-literature
UnknownHealth and economic burden due to malaria in Peru over 30 years (1990-2019): Findings from the global burden of diseases study 2019.
Not available
S-EPMC9903979 | biostudies-literature
UnknownEffectiveness of a Primary Care Telerehabilitation Program for Post-COVID-19 Patients: A Feasibility Study.
Not available
S-EPMC8509356 | biostudies-literature
UnknownDesign and Cross-Cultural Invariance of the COVID-19 Vaccine Conspiracy Beliefs Scale (COVID-VCBS) in 13 Latin American Countries.
Not available
S-EPMC9237359 | biostudies-literature
UnknownWhat Is the Support for Conspiracy Beliefs About COVID-19 Vaccines in Latin America? A Prospective Exploratory Study in 13 Countries.
Not available
S-EPMC9120924 | biostudies-literature
TranscriptomicsIdentification of differentially regulated genes in Populus deltoides subjected to copper stress using 4.6K cDNA arrays
cDNA macroarray expression profiling was carried out in poplar roots in order to identify genes regulated in response to exposition to copper stress. For this purpose, plants of a Populus deltoides clone grown in a hydroponic system during four weeks were incubated in a nutrient solution (Hoagland'...
ORGANISM(S): Populus deltoides 
2010-05-06 | E-GEOD-9748 | biostudies-arrayexpress
UnknownCross-cultural validation of the new version of the Coronavirus Anxiety Scale in twelve Latin American countries.
Not available
S-EPMC8765828 | biostudies-literature
UnknownHaplotype analysis of the internationally distributed BRCA1 c.3331_3334delCAAG founder mutation reveals a common ancestral origin in Iberia.
Not available
S-EPMC7579869 | biostudies-literature
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