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TranscriptomicsRapamycin effect on gene expression: dependence on c-Myc
This experiment utilized rat fibroblasts that are wild-type for c-Myc (TGR-1 cells) and null for c-Myc (HO15.19 cells). Both were treated treated with rapamycin for 24 hr (comparison group, vehicle control). Cells were studied under conditions that supported proliferation. Rapamycin (50nM or DMSO ...
ORGANISM(S): Rattus norvegicus 
2010-10-25 | E-GEOD-18845 | biostudies-arrayexpress
TranscriptomicsGene expression data from rapamycin resistant and sensitive cell lines
The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tumorgenesis we hypothesized that miRNAs could play important roles in the response of tumors to mTOR i...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-19885 | biostudies-arrayexpress
TranscriptomicsTLR-mediated type I IFN induction in pDCs requires the rapamycin-sensitive PI3K-mTOR-p70S6K pathway
Robust type I interferon (IFN-alpha/beta) production in plasmacytoid dendritic cells (pDCs) is critical for anti-viral immunity. Here we demonstrated a role for the mammalian target of rapamycin (mTOR) pathway in regulating interferon production by pDCs. Inhibition of mTOR or the ‘downstream’ mediat...
ORGANISM(S): Mus musculus 
2008-12-01 | E-GEOD-12218 | biostudies-arrayexpress
TranscriptomicsMicroRNAs mediate rapamycin resistance in a myogenic tumor cell line
The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tumorgenesis we hypothesized that miRNAs could play important roles in the response of tumors to mTOR i...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-19916 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human rapamycin treated of MDA-MB-468 breast cancer cell line and MDA-MB-468 xenografts
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in multiple intracellular signaling pathways promoting tumor growth. mTOR is aberrantly activated in a significant portion of breast cancers and is a promising target for treatment. Rapamycin and its analogues are in clinical...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-18571 | biostudies-arrayexpress
TranscriptomicsSch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae
The Target Of Rapamycin (TOR) protein is a Ser/Thr kinase that functions in two distinct multiprotein complexes: TORC1 and TORC2. These conserved complexes regulate many different aspects of cell growth in response to intra- and extracellular cues. Here we report the first bona fide substrate of yea...
ORGANISM(S): Saccharomyces cerevisiae 
2010-09-15 | E-GEOD-7660 | biostudies-arrayexpress
TranscriptomicsExpression data from rapamycin treatment and/or p73 knock-down in Rh30 cells
p73 is a p53 family transcription factor that plays critical roles during development and tumor suppression. We analyzed p73 activity using a combination of ChIP-on-Chip and gene expression profiling, both at baseline and after treatment with the mTOR inhibitor rapamycin. We generated an mTOR-p73 g...
ORGANISM(S): Homo sapiens 
2011-01-05 | E-GEOD-15703 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse TSC2-/- embryonic fibroblasts: vehicle-treated, rapamycin-treated, gfp-infected, and pgc-1alpha-infected samples reveals the mTOR pathway controls mitochondrial gene expression and respiration through the YY1/PGC-1alpha transcriptional complex
Mitochondrial oxidative function is tightly controlled to maintain energy homeostasis in response to nutrient and hormonal signals. An important cellular component in the energy sensing response is the target of rapamycin (TOR) kinase pathway; however whether and how mTOR controls mitochondrial oxid...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5332 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of effector T cells induced by mTOR inhibition
To further develop our gene expression approach to treatment of autoimmunity, we have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed upon immunosuppressor treatment responsible for inhibition of T cell effector functions. Huma...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-29606 | biostudies-arrayexpress
ProteomicsAssessing protein level changes following inhibition of the mechanistic target of rapamycin
This study focused on determining changes in protein levels following inhibition of the mechanistic target of rapamycin using mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2025-09-20 | PXD049052 | Pride
Target of rapamycin 
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